At any given time, there are many cells in our body that are in the process of dividing, yet they almost never go out of control to give rise to cancers. Cell proliferation is normally kept in check by a group of gatekeeper genes called "tumor suppressors". Of these, the Ink4a/ARF locus has been of considerable interest since this locus is inactivated in a majority of human cancers. This locus encodes two different proteins that act together to check uncontrolled tumor development.
A study to be published in the November 15 issue of Genes and Development illustrates the importance of these gene products in controlling cancer in mammals. The Tumor Suppressor group headed by Manuel Serrano at the Spanish National Cancer Center (CNIO) has used recombinant DNA technology to generate transgenic mice carrying an extra copy of the Ink4a/ARF tumor suppressor locus. The resulting "Super Ink4a/Arf" mice carry three copies of the Ink4a/Arf genes and were compared to their normal littermates that lacked the transgene and had only two copies.
These mice were put through a battery of tests and were found to be significantly resistant to a variety of tumorigenic stimuli. Cells derived from the super Ink4a/Arf mice were more resistant to acquiring the ability to divide indefinitely and alterations by oncogenes, two important features of a successful cancer. In addition, the animals developed cancers at a much lower rate upon treatment with different types of carcinogens. The presence of an extra copy of these genes and increased cancer resistance had no apparent effect on the lifespan or fertility of these "supermice". These results are consistent with earlier work done by
Heather Cosel Pieper | EurekAlert!
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy