Research uncovers role of Apolipoprotein E in Alzheimers disease
Inhibiting Apolipoprotein E possible means of therapeutic intervention for Alzheimers disease
A research team led by University of South Florida neuroscientist Huntington Potter, PhD, CEO of the Johnnie B. Byrd Sr. Alzheimers Center & Research Institute, for the first time has defined how the protein Apolipoprotein E (ApoE) contributes to both the formation of amyloid brain lesions and the memory loss associated with Alzheimers disease. The research, conducted jointly by USF and the Byrd Institute, is published in the October 2004 issues of the Journal of Alzheimers Disease and the Neurobiology of Aging.
Previous work has shown that the inflammatory protein ApoE can speed the buildup in the brain of amyloid plaques, the major pathological hallmark of Alzheimers disease. These deposits of plaques are composed primarily of the amyloid-beta protein (AB). However, the mechanism by which ApoE exerted its ill effects on Alzheimers disease was unclear.
In the first paper*, published in the Journal of Alzheimers Disease, the USF/Byrd Institute team found that ApoE is responsible for converting harmless AB into the toxic fibrous deposits, known as filamentous amyloid. The researchers showed that mice with ApoE possessed 3200 times more filamentous amyloid than those without the gene. Diffuse deposits of AB can occur in the elderly in the absence of Alzheimers disease, and are thought to be a normal aspect of aging, while filamentous amyloid is a toxic product of Alzheimers disease.
In the second paper**, published in the Neurobiology of Aging, the researchers indicate that the process of altering AB from its diffuse form into filamentous amyloid is needed to damage nerve cells in parts of the brain controlling memory and cognition. Mice with Alzheimers disease showed memory deficits only when the ApoE gene was present.
"The implication of these studies is that the amyloid promoting activity of ApoE is essential for the development of both Alzheimers pathology and cognitive decline," said Dr. Potter, professor of biochemistry and molecular biology who holds the Pfeiffer Endowed Chair in Alzheimers Research at USF. "Thus, preventing ApoE from acting upon AB may prove to be an effective means of therapeutic intervention."
Anne DeLotto Baier | EurekAlert!
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