Researchers at the University of Minnesota Stem Cell Institute are one step closer to understanding how blood cells develop through the use of human embryonic stem cells. The research better defines the conditions under which blood cell development occurs, making the process easier to replicate. The findings are published in the October issue of Experimental Hematology.
"These findings do more than give us a basic understanding of blood cell replacement--they allow us to consider potential future therapies," said Dan Kaufman, M.D., assistant professor of medicine in the division of hematology, oncology and lead researcher. "We can envision blood therapies completely compatible with the patient, such as use of embryonic stem cells to make red blood cells for platelets used in blood transfusions, or a source of new blood supply free of any viruses. They might also be a source for bone marrow transplants, especially for those patients who do not otherwise have an appropriately matched donor."
This process is also significant because the blood cells were developed without the use of animal serum, which was previously thought to be essential for blood cell development. Instead, specific growth factors are added to guide the cell differentiation. These results are important for potential human application. Animal serum can potentially contaminate findings and create complications for human trials.
Molly Portz | EurekAlert!
Rochester scientists discover gene controlling genetic recombination rates
23.04.2018 | University of Rochester
One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie
Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
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University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
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Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
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