Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tests begin of flu vaccine grown in insect cell lines

26.10.2004


Scientists are launching a research study to check the effectiveness of a new type of flu vaccine that is made differently than the conventional vaccine, which is grown in eggs. The experimental vaccine instead relies on a cell line drawn from insects known as silk moths, which are better known for their role as pests attacking crops such as corn, cotton, barley and alfalfa.



The study of FluBlOk, made by Protein Sciences Corp. of Meriden, Ct., was initiated by flu expert John Treanor, M.D., professor of medicine and director of the Vaccine and Treatment Evaluation Unit at the University of Rochester Medical Center. The study will include a total of 400 to 500 adults ages 18 to 49 at three sites: Rochester, the University of Virginia, and Cincinnati Children’s Hospital.

Since the 1940s the chicken has been at the center of flu vaccination efforts, because fertilized chicken eggs are used to grow the flu viruses used in vaccines. Each egg contains less than a teaspoonful of material that will ultimately become part of a vaccine. Because of the complexity and sheer size of the process – tens of millions of eggs must be produced, and vaccine material must be "harvested" from each – it’s typically a six-month process to produce enough vaccine for the public, when everything goes well.


Using a cell line instead of eggs to produce the vaccine would likely slice one or two months off the production process, says Treanor. That could reduce costs and also give scientists and physicians more time each year before they decide on that year’s vaccine makeup, giving them crucial time to watch the spread of flu of around the globe and concoct a vaccine. Producing biological products in insect cell lines is common; the hepatitis B vaccine, for instance, is produced by human cell lines, and scientists from Rochester have developed an experimental vaccine against human papilloma virus using an insect cell line.

Reduced costs might also make it possible to boost the dose that patients receive. Last year in a study of the same product in 399 elderly people, Treanor found that people who had received more vaccine made twice as many antibodies to ward off flu than healthy people who got the conventional vaccine.

The new study is only for healthy people ages 18 through 49 who will not be getting a flu shot otherwise. The study will not include anyone from high-risk groups, such as pregnant women, people with pulmonary disease, the elderly, or health care workers. Those people should be vaccinated with conventional vaccine, which is known to work; the current study is testing an experimental vaccine to see whether it’s effective.

Tom Rickey | EurekAlert!
Further information:
http://www.rochester.edu

More articles from Life Sciences:

nachricht Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel

nachricht The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Tracking movement of immune cells identifies key first steps in inflammatory arthritis

23.01.2017 | Health and Medicine

Electrocatalysis can advance green transition

23.01.2017 | Physics and Astronomy

New technology for mass-production of complex molded composite components

23.01.2017 | Process Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>