Scientists at Scripps Research Institute use drug to stabilize blood vessels and block metastatic cancer cells from leaving the bloodstream
A team of scientists at The Scripps Research Institute has identified a potential treatment strategy against metastatic cancer cells that has never been tried before. Metastasis is a major problem with cancer because it allows tumor cells to spread to other parts of the body (See Supporting Material: Cancer and Metastasis). While solid tumors can be removed surgically or treated with chemotherapy or radiation, metastatic cells that have already entered the circulation are capable of opening a passageway through blood vessels in order to spread to various organs throughout the body.
Once tumor cells leave their primary tumor, they enter the blood stream and ultimately must find an exit strategy in order to set up new "satellite" lesions in one or more distant organs. The potential treatment strategy targets this final step of the metastatic cascade--the exit of the metastatic cells from the bloodstream. "We know that the normal blood vessel wall is one final barrier that metastatic tumor cells must overcome, which allows them to find their way out of the bloodstream and into a metastatic site," says Immunology Professor David A. Cheresh, who led the research with postdoctoral fellow Sara Weis at The Scripps Research Institute. To exit the blood stream, says Cheresh, the tumor cells stimulate the local blood vessels to briefly open their cell-cell junctions so that they can implant themselves into a new organ site.
Atomic-level motion may drive bacteria's ability to evade immune system defenses
24.04.2017 | Indiana University
Two-dimensional melting of hard spheres experimentally unravelled after 60 years
24.04.2017 | University of Oxford
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
24.04.2017 | Physics and Astronomy
24.04.2017 | Materials Sciences
24.04.2017 | Life Sciences