Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene for diabetes found

25.10.2004


A gene involved in the action of insulin is associated with type 2 diabetes and the body’s response to insulin, report scientists at Wake Forest University Baptist Medical Center.



Donald W. Bowden, Ph.D., the principal investigator, and his colleagues described the gene in two articles in the November issue of Diabetes, a journal of the American Diabetes Association.

Bowden said the gene is called PTPN1 (Protein Tyrosine Phosphatase N1) and is found on the human chromosome 20, which has long been targeted by investigators as a likely site for diabetes genes. "The protein that this gene makes represses the insulin response, so if you are making a lot of this protein, your ability to respond to insulin would be blunted, which would lead to higher glucose (sugar) in your bloodstream. If it is too high, that’s diabetes," said Bowden, professor of biochemistry and internal medicine - endocrinology. The researchers found several variants of the PTPN1 gene, he said. "One common form is associated with diabetes, and there’s another common form that appears to be protective."


The risky variant of PTPN1 gene is found in about 35 percent of the Caucasian population and the protective form of PTPN1 is found in about 45 percent. The other variants are apparently neutral, neither enhancing nor reducing the risk of diabetes. "There are certainly other genes that contribute to diabetes," Bowden said. "This is good evidence for one." The researchers found a "remarkably similar pattern" in Hispanics. "In Hispanic families, people who had the risky form of the gene did not respond to insulin well and had higher levels of glucose in their blood – both risk factors for diabetes."

Bowden said the newly discovered gene could be a significant contributor to diabetes in Americans. With Josyf C. Mychaleckyj, "we’ve carried out calculations to try to assess how much of an impact the different forms of this gene have on diabetes in the population. The best guess right now is it contributes to about 20 percent of diabetes in Caucasian Americans."

But the picture becomes more complex in other racial groups. "The effect doesn’t seem to be there in African-Americans," Bowden said. Other genes may be responsible for diabetes in African-Americans, and the research team is pursuing those genes.

Bowden said the research was conducted in three population studies. The first group involved 300 Caucasian patients with type 2 diabetes and end-stage kidney disease, matched with 310 unrelated Caucasian subjects who do not have diabetes. The results were confirmed in a second completely independent group of 275 Caucasians with diabetes who are participating in the Diabetes Heart Study and a 200-person control group.

The third group was from the IRAS Family Study (Insulin Resistance Atherosclerosis Family Study), a national study in which Wake Forest investigators based in the Department of Public Health Sciences and the Center for Human Genomics are major contributors. The analysis focused on Hispanic IRAS participants and their families – brothers, sisters, fathers, mothers, and children. In 811 Hispanic participants in the study, the results "are completely consistent" with the results among Caucasians, Bowden said.

He said fifth-year graduate student Jennifer Bento used the latest genetic technologies to work through the entire region of chromosome 20, "genotyped hundreds of markers," and found the different forms of PTPN1.

Besides Bowden, Bento and Mychaleckyj, the team also included Nicholette D. Palmer, Leslie A. Lange, Carl D. Langefeld , Ph.D., and Stephen Rich. Ph.D. of Public Health Sciences and Barry I. Freedman, M.D., a nephrologist.

Karen Richardson | EurekAlert!
Further information:
http://www.wfubmc.edu

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

DGIST develops 20 times faster biosensor

24.04.2017 | Physics and Astronomy

Nanoimprinted hyperlens array: Paving the way for practical super-resolution imaging

24.04.2017 | Materials Sciences

Atomic-level motion may drive bacteria's ability to evade immune system defenses

24.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>