Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Alternative tests with better results and less use of animals

25.10.2004


There is a patent demand in the pharmaceutical, cosmetic and chemical industry for new alternative testing in order to assess the acute toxicity of new drugs, cosmetic ingredients or industrial chemical products that have to be in contact with humans or the natural environment.



The aim is to reduce the time for and cost of studies for the development of new active elements and reduce the number of experimental animals. Equally, these tests enable direct work on human cell lines instead of on animals, in order to study the toxicity of the liver or kidney, amongst other organs.

To this end, the validation of this new in vitro work methodology, compared to the conventional in vivo one is urgently needed, not only by corporate industry but also by the European Directives themselves. Both REACH (the UE regulating body for chemical products) and the 7th amendment to the Directive on cosmetics propose the replacement in, the short term, of animal experimentation. Currently, while a number of animal testing procedures for toxicity have been successfully substituted by alternative methods, systemic toxicities require new strategic tests to reach a suitable level of safety for the consumer.


In this context, and thanks to its potential in terms of infrastructure as well as qualified and experienced personnel (BPL certificates -10.BPLI/98.01/001 MSC-), in August 2003 GAIKER became part of A-Cute-Tox, a platform financed by the UE and made up of 37 companies and research centres (Integrated Project) drawn from 13 European countries. Its aim is to develop a simple and robust in vitro testing strategy for the prediction of acute human systemic toxicity, which can substitute the tests for acute animal toxicity currently used as regulators.

This approach requires the dimensions of a transnational integrated project, and the involvement of prominent toxicity research groups in the European Union, strict supervision and the introduction of the regulating community and professional handling. It offers the real possibility of getting a substantial reduction of experiments with acute animal systemic toxicity. The involvement of the European Centre for Validation of Alternative Methods (ECVAM) in the management of the project and the other regulatory bodies, such as the ECB (European Chemicals Bureau), guarantees control of the final goal of the project.

Jose Maria Goenaga | Basque research
Further information:
http://www.gaiker.es

More articles from Life Sciences:

nachricht Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute

nachricht Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>