Researchers at Cedars-Sinai’s Maxine Dunitz Neurosurgical Institute have described an immune-disruptive process driven by an enzyme that is overexpressed in the cells of many types of tumors, including malignant brain tumors called gliomas.
Blocking the enzyme’s expression in laboratory tests interrupted the series of cell-level events and led to the development of cells capable of launching an immune response. This finding supports the suggestion that medications attacking the enzyme may boost the immune system’s ability to recognize and target gliomas.
Results of the study on cyclooxygenase-2 (COX-2) appear in the October 1 issue of the Journal of Immunology. While COX-2 inhibition has been considered an attractive anti-cancer strategy, results of earlier studies on a variety of tumors have been inconsistent, puzzling and sometimes seemingly contradictory. Furthermore, because COX-2 is a complex enzyme that is affected by a variety of conditions and biochemical substances, many of its mechanisms and effects are not clearly understood.
Sandra Van | EurekAlert!
Polymers Based on Boron?
18.01.2018 | Julius-Maximilians-Universität Würzburg
Bioengineered soft microfibers improve T-cell production
18.01.2018 | Columbia University School of Engineering and Applied Science
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
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