Estrogen treatment had less beneficial effect on memory in female mice that raced on running wheels and played with other toys than in mice raised in non-stimulating environments, according to a Yale study published this month.
"We saw no beneficial effect of estrogen in the animals in cognitively and physically stimulating environments (also known as enriched environments)," said Karyn Frick, assistant professor of psychology and principal investigator on the study. "This fits in nicely with human data and might help to explain why studies of hormone replacement therapy (HRT) do not show beneficial effects for all women. Most studies of HRT use very well-educated women. These results might spur researchers to include a broader population with a greater variation in education and socioeconomic status."
All of the mice lived in standard housing conditions that contained other mice and no toys. However, enriched mice spent three hours each day in larger cages with running wheels, tubes, and other mouse toys. The toys were varied from day to day. At 10 weeks of age, the ovaries of the mice were removed to simulate the long-term estrogen losses seen in menopause. At six months of age, the mice were then treated with estrogen or a control substance and were tested in tasks measuring spatial memory and memory for objects.
Jacqueline Weaver | EurekAlert!
Enduring cold temperatures alters fat cell epigenetics
19.04.2018 | University of Tokyo
Full of hot air and proud of it
18.04.2018 | University of Pittsburgh
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
In an article that appears in the journal “Review of Modern Physics”, researchers at the Laboratory for Attosecond Physics (LAP) assess the current state of the field of ultrafast physics and consider its implications for future technologies.
Physicists can now control light in both time and space with hitherto unimagined precision. This is particularly true for the ability to generate ultrashort...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
19.04.2018 | Materials Sciences
19.04.2018 | Physics and Astronomy
19.04.2018 | Physics and Astronomy