Researchers have identified a new gene that causes a common form of inherited Parkinsons disease (PD) and whose understanding they believe "will impact not only patients and their families but will open novel avenues of research aimed at identifying and ultimately halting the molecular events that lead to PD."
The international research team reported finding the gene in a mutant form in five families from Spain and the United Kingdom. They have named the protein "dardarin" after the Basque word for tremor. The researchers, led by Jordi Pérez-Tur, Nick Wood, and Andrew Singleton, were seeking to pinpoint the gene that caused a form of PD called PARK8, which was first reported in 2002. Their search was spurred by the knowledge that earlier discoveries of other genetic mutations underlying rare forms of PD had yielded insight into PD and aided design and testing of drug treatments.
Until their studies, it was only known that PARK8 was caused by a mutation in a gene somewhere along a chromosomal region, or locus, that contained about 116 genes. The researchers had identified four families from the Basque region of Spain and one from the United Kingdom that showed evidence of having PARK8 PD. Their systematic analyses of the PARK8 locus led them to track down mutations that all had in the gene encoding dardarin.
Heidi Hardman | EurekAlert!
More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
19.01.2018 | Materials Sciences
19.01.2018 | Health and Medicine
19.01.2018 | Physics and Astronomy