Researchers at Yale and Syracuse Universities found the first direct evidence for a mutation in mitochondrial DNA that directly affects blood pressure and cholesterol levels.
It has long been known that several metabolic traits including high cholesterol and hypertension cluster in individuals more frequently than by chance, but the underlying causes were unknown. This study, published early in Science Express on line, suggests that altered mitochondria may account for the clustering as well as the disorders. "Looking further, this finding raises the possibility that all features of the metabolic syndrome may be attributable to altered mitochondrial function," said Richard T. Lifton, Sterling Professor and Chair of Genetics at Yale and research team leader.
Metabolic syndrome is an emerging problem in industrial societies and. epidemic in the United States. The symptoms include high blood pressure, cholesterol and triglycerides, insulin resistance, obesity, and low HDL. There is independent evidence that altered mitochondrial function plays a role in insulin resistance and high triglyceride level, and the current finding indicates that these other components of metabolic syndrome may also linked to mitochondrial disfunction.
Janet Rettig Emanuel | EurekAlert!
Rochester scientists discover gene controlling genetic recombination rates
23.04.2018 | University of Rochester
One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
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