Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Are yeast cells bringing us a step closer in treating obesity?

22.10.2004


For the first time, researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected with the Catholic University of Leuven have shown clearly that receptors in yeast cells detect and react to nutrients in the cell. The chance is great that this is also the case with human cells. Because about 40% of today’s medicines act on receptors in our cells, this research opens new possibilities for the treatment of metabolic disorders such as diabetes and obesity.

Detecting sugars in the cell

Every living thing is composed of cells, which communicate with each other and the external world by means of receptor proteins on the cell membrane. These proteins receive signals from outside the cell by binding themselves with particular substances (such as hormones), which then produces a reaction by the cell to regulate processes internal or external to the cell. A number of medicines play on this cellular operation to produce beneficial responses for our health. Now, for the first time, Katleen Lemaire and her colleagues, under the direction of Johan Thevelein of VIB and the Catholic University of Leuven, have discovered receptor proteins in yeast cells that detect and react to glucose and sucrose.



The detection of glucose, the transport sugar in the blood, is of major importance for all the cells in the body. Glucose is not only absorbed and metabolized by the cells - it also regulates many cellular reactions. When too much or too little glucose is present in the blood - as in diabetes, for example - this process can break down. The discovery that receptor proteins react to sugars like glucose is very important to the search for treatments for metabolic diseases. Indeed, these proteins could be good targets for new medicines to compensate for the surplus or shortage of a particular sugar.

Yeast as model for humans

The VIB scientists are conducting their research on yeast proteins. It often turns out that the proteins found in yeast have a similar variant in human cells. This makes yeast an excellent model organism for learning more about mechanisms in humans and animals. There has long been a question about whether mammals have glucose receptors. The discovery of such receptors in yeast considerably raises the possibility of their existence in human beings.

Given that this research can raise a lot of questions for patients, we ask you to please refer questions in your report or article to the email address that VIB makes available for this purpose: patienteninfo@vib.be. Everyone can submit questions concerning this and other medically-oriented research directly to VIB via this address.

Sooike Stoops | EurekAlert!
Further information:
http://www.vib.be

More articles from Life Sciences:

nachricht Researchers identify potentially druggable mutant p53 proteins that promote cancer growth
09.12.2016 | Cold Spring Harbor Laboratory

nachricht Plant-based substance boosts eyelash growth
09.12.2016 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>