By knocking out a single gene in mice, immunologists at Duke University Medical Center have mimicked a little-understood autoimmune disorder in humans. In the puzzling disorder, called Sjögrens syndrome, the persons tear and salivary glands are affected, causing dry eyes and mouth, as they are damaged by an attack of the persons own immune cells.
According to researchers, the achievement not only offers insight into Sjögrens syndrome, but into the general developmental machinery of the immune system. The immunologists, Yuan Zhuang, HongMei Li and MeiFang Dai, published their findings in the October 2004 issue of the journal Immunity. The work was sponsored by the National Institutes of Health and the Leukemia and Lymphoma Society.
In a preview of the article, immunologist Marjan Versnel wrote that the new mouse model "offers a wonderful opportunity to study in detail the relationship between the immune system and autoimmunity occurring in the context of only a single genetic lesion." Versnel is at Erasmus Medical Center in the Netherlands.
Dennis Meredith | EurekAlert!
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Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
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Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
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