Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Experimental lupus drug may also work against atherosclerosis

18.10.2004


A drug that reduces symptoms of systemic lupus in mice may turn out to be effective against hardening of the arteries and thus prevent heart attacks, according to two poster presentations today at the American College of Rheumatology meeting in San Antonio.



Nilamadhab Mishra, M.D., of Wake Forest University Baptist Medical Center, said the drug, called Trichostatin A or TSA, "may have a therapeutic benefit in atherosclerosis," which causes coronary artery disease by blocking key arteries, leading to death and disability. Mishra, assistant professor of internal medicine – rheumatology, and his colleagues tested TSA on experimental mice that were bred to lack a significant natural protection against atherosclerosis. For 12 weeks, these mice were fed a diet that was both high in cholesterol and in which 10 percent of calories came from palm oil, one of the vegetable oils most likely to cause atherosclerosis. In addition to the coronary arteries, atherosclerosis also occurred in the aortic arch, part of one of the body’s main blood vessels.

When Mishra compared the mice given TSA with mice given an inert substance, the amount of atherosclerosis deposited in the aortic arch was cut in half. The TSA-treated mice also had a reduction in total and free cholesterol levels in the abdominal aorta, the lower portion of the aorta, the body’s largest blood vessel.


These mice had a three-fold reduction in the gathering of macrophages, a type of white blood cell. Scientists increasingly are viewing the depositing of cholesterol in the walls of arteries as an inflammatory reaction that attracts the disease-fighting macrophages, which then become incorporated with cholesterol deposits to become plaque.

"The recognition of atherosclerosis as an inflammatory disease raised the question of whether anti-inflammatory drugs might decrease this disease process," said Mishra, who noted that TSA is not only an anti-cancer and anti-lupus drug, but also an anti-inflammatory agent. TSA treatment changed the composition of the atherosclerotic deposit in a way that may lead to plaque stability, so pieces don’t break off so easily. The breaking off of plaques, which then can lodge elsewhere in already narrowed arteries, is a key mechanism for heart attacks and strokes.

Mishra got similar results when he tested TSA on another type of experimental mice that are also prone to atherosclerosis. He said a gene called CD154 causes both atherosclerosis and lupus. "This drug inhibits both."

Mishra’s team included John S. Parks, Ph.D., professor of pathology (comparative medicine), Anh Nghiem, B.S., Elene Boudyguina, B.S., and Doris R. Brown, Ph.D., all at Wake Forest Baptist, and Samantha Laclair. B.S., and Uwe Schonbeck, Ph.D., of Brigham and Women’s Hospital of Harvard Medical School in Boston.

Robert Conn | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>