Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Excess dietary fat accelerates breast cancer by altering the activity of a group of genes

18.10.2004


Breast cancer is the most frequent form of cancer in women around the world. The fact that this cancer is more frequent in the developed world suggests that life style and environmental factors may be involved. Nutritional factors are particularly important, given people’s continual exposure through dietary habits. Among them, dietary fats are the main element involved in breast cancer. Fats do not cause cancer, however some of them, such as animal fats or certain vegetable fats, accelerate the clinical development of the disease, while blue fish and olive oil appear to delay its development.



A research team headed by Dr. Eduard Escrich, lecturer in the Departament de Biologia Cel·lular, de Fisiologia i d’Immunologia at the Universitat Autònoma de Barcelona and head of the Grup Multidisciplinari per a l’Estudi del Càncer de Mama (Multi-disciplinary group on Breast Cancer Studies) has established a specific mechanism by which some of these fats favour the development of breast cancer. According to research, diets rich in the polyunsaturated fatty acids n-6 reduce the expression of a group of four genes, three of which are related to cellular differentiation (a-2u-globulin, VDUP1 and H19) and the fourth of which is a sequence with a totally unknown function (known as EST Rn.32385), thereby accelerating the proliferation of tumours.

The scientists have reached these conclusions from results, obtained using microarrays, that compare the expression of 6,000 genes in breast cancer tumours in animals fed with n-6 fat-rich diets and in animals with low-fat diets. The tumours in the rats with the fat-rich diets proliferated, on average, more than the others, apparently associated with a lesser expression of the four genes. According to the UAB researchers, in an article published in Molecular Carcinogenesis, “this is the first time that the influence of a fat-rich diet on the expression of these genes has been investigated. The discovery opens a new line of research into its implication in changes on the state of cellular differentiation induced by dietary lipids in breast cancer tumours and the degree of malignity of the cancer.


In general, the research carried out by the Grup Multidisciplinari per a l’Estudi del Càncer de Mama aims to establish possible activity of common elements in human diet, beyond the nutritional value, which may permit scientific opinions to be formulated on the health of the population of the risk of disease. It is therefore involved in the field of secondary and especially primary prevention of breast cancer.

Octavi López Coronado | alfa
Further information:
http://www.uab.es

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Atomic-level motion may drive bacteria's ability to evade immune system defenses

24.04.2017 | Life Sciences

Two-dimensional melting of hard spheres experimentally unravelled after 60 years

24.04.2017 | Life Sciences

Molecular libraries for organic light-emitting diodes

24.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>