Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Excess dietary fat accelerates breast cancer by altering the activity of a group of genes

18.10.2004


Breast cancer is the most frequent form of cancer in women around the world. The fact that this cancer is more frequent in the developed world suggests that life style and environmental factors may be involved. Nutritional factors are particularly important, given people’s continual exposure through dietary habits. Among them, dietary fats are the main element involved in breast cancer. Fats do not cause cancer, however some of them, such as animal fats or certain vegetable fats, accelerate the clinical development of the disease, while blue fish and olive oil appear to delay its development.



A research team headed by Dr. Eduard Escrich, lecturer in the Departament de Biologia Cel·lular, de Fisiologia i d’Immunologia at the Universitat Autònoma de Barcelona and head of the Grup Multidisciplinari per a l’Estudi del Càncer de Mama (Multi-disciplinary group on Breast Cancer Studies) has established a specific mechanism by which some of these fats favour the development of breast cancer. According to research, diets rich in the polyunsaturated fatty acids n-6 reduce the expression of a group of four genes, three of which are related to cellular differentiation (a-2u-globulin, VDUP1 and H19) and the fourth of which is a sequence with a totally unknown function (known as EST Rn.32385), thereby accelerating the proliferation of tumours.

The scientists have reached these conclusions from results, obtained using microarrays, that compare the expression of 6,000 genes in breast cancer tumours in animals fed with n-6 fat-rich diets and in animals with low-fat diets. The tumours in the rats with the fat-rich diets proliferated, on average, more than the others, apparently associated with a lesser expression of the four genes. According to the UAB researchers, in an article published in Molecular Carcinogenesis, “this is the first time that the influence of a fat-rich diet on the expression of these genes has been investigated. The discovery opens a new line of research into its implication in changes on the state of cellular differentiation induced by dietary lipids in breast cancer tumours and the degree of malignity of the cancer.


In general, the research carried out by the Grup Multidisciplinari per a l’Estudi del Càncer de Mama aims to establish possible activity of common elements in human diet, beyond the nutritional value, which may permit scientific opinions to be formulated on the health of the population of the risk of disease. It is therefore involved in the field of secondary and especially primary prevention of breast cancer.

Octavi López Coronado | alfa
Further information:
http://www.uab.es

More articles from Life Sciences:

nachricht Discovery of a Key Regulatory Gene in Cardiac Valve Formation
24.05.2017 | Universität Basel

nachricht Carcinogenic soot particles from GDI engines
24.05.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>