Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis
As cancer progresses, cancer cells acquire the ability to become resistant to programmed-cell-death, called apoptosis. Understanding the molecular mechanisms involved in the regulation of apoptosis is key for developing proper cancer therapies. Survivin is a member of a family of proteins that are inhibitors of apoptosis (IAPs), but the means by which survivin inhibits apoptosis remains largely unknown. Dario Altieri and colleagues, from the University of Massachusetts Medical School, investigated the where survivin is located within the cell to see whether the cellular location is directly involved in the regulation of apoptosis and the establishment and progression of tumors.
The authors identified a specific mitochondrial pool of survivin that is released into the cytoplasm when a cell receives signals to undergo cell death. Once in the cytoplasm, survivin inhibits enzymes called caspases which are required for apoptosis, and in doing so, blocks apoptosis. The researchers showed that by selectively targeting survivin to the mitochondria this enhanced soft agar colony formation, which is a standard laboratory technique to test for cells that lack growth control and are potentially tumor forming. In mice, when the authors carried out such mitochondrial targeting of survivin, this resulted in increased tumor growth and eleimination of apoptosis. The data here demon-strate a novel pathway for apoptosis inhibition and tumor progression.
Laurie Goodman | EurekAlert!
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At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
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There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
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The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
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