Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis
As cancer progresses, cancer cells acquire the ability to become resistant to programmed-cell-death, called apoptosis. Understanding the molecular mechanisms involved in the regulation of apoptosis is key for developing proper cancer therapies. Survivin is a member of a family of proteins that are inhibitors of apoptosis (IAPs), but the means by which survivin inhibits apoptosis remains largely unknown. Dario Altieri and colleagues, from the University of Massachusetts Medical School, investigated the where survivin is located within the cell to see whether the cellular location is directly involved in the regulation of apoptosis and the establishment and progression of tumors.
The authors identified a specific mitochondrial pool of survivin that is released into the cytoplasm when a cell receives signals to undergo cell death. Once in the cytoplasm, survivin inhibits enzymes called caspases which are required for apoptosis, and in doing so, blocks apoptosis. The researchers showed that by selectively targeting survivin to the mitochondria this enhanced soft agar colony formation, which is a standard laboratory technique to test for cells that lack growth control and are potentially tumor forming. In mice, when the authors carried out such mitochondrial targeting of survivin, this resulted in increased tumor growth and eleimination of apoptosis. The data here demon-strate a novel pathway for apoptosis inhibition and tumor progression.
Laurie Goodman | EurekAlert!
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Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.
The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
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