Requirement for sphingosine 1–phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference
Tumor growth and metastasis require new blood ves-sel growth, a process called angiogenesis. There are many factors involved in the nor-mal growth and stabilization of new blood vessels. One of these, sphingosine 1-phosphate receptor 1 (S1P1), is required during embryonic development to stabilize new blood vessels. Timothy Hla and colleagues, from the University of Connecticut Health Science Center, inves-tigated the importance of S1P1 in angiogenesis in tumors. The authors implanted mice with Lewis lung carcinoma cells and examined tissue sections for S1P1 expression. S1P1 expression was found in the blood vessels only in the areas around the implanted tumor.
The researchers then developed an RNA interference technique, a method that specifically blocks S1P1 expression. They showed that using RNA interference they successfully blocked S1P1 expression in cell culture and that when they injec-tion of the S1P1-specific interfering RNA into tumors in mice, these also showed repressed S1P1 expres-sion. In conjunction with loss of S1P1 expression, new blood vessel stabilization and growth were compromised and tumor growth suppressed in vivo. This study indicates both that S1P1 is vital for blood vessel growth in tumors and that RNA interference technology may be of great use in anticancer therapies.
Laurie Goodman | EurekAlert!
Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
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Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
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Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
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