Analysis To Identify Cancer
An amazingly sensitive method for selective analysis of amino acids, sugars, fatty acids, and other vital compounds has been developed by Russian scientists. This method allows determining even their trace quantities (fractions of nanograms). It is applicable in identifying cancerous cells and diagnostics of cancer at the earliest stage, when traditional diagnostics fail to catch sight of the disease.
Dr. Igor Revel’sky and his colleagues from the Moscow State University have developed method that provides a 100-times increased sensitivity of detecting amino acids and other vital compounds, i.e., a highest precision of their detection. This can be used in controlling the quality of drugs and foods and, prospectively, may become an effective technique of cancer diagnostics that will be more reliable than traditional histology.
The Russian scientists propose to begin with the separation of a complex mixture (e.g., the contents of a cell suspected of cancer). They separate firstly water-soluble substances from the rest of the mixture and, then, treat each of the two obtained fractions with specific reagents. As a result, the analyzed substances become volatile and separable with the use of a gas chromatograph, in which they are diffused along with a carrier gas through a liquid or solid adsorbent for differential adsorption. Each component produces its own peak in chromatogram.
The next challenge is identifying the components and their concentrations. This is rather difficult, as investigated samples contain a great variety of components, and a universal type of detector with a high sensitivity is needed. Such a detector chosen by the Russian scientists is a mass spectrometer. This apparatus is rather expensive and requires special operation skills. It converts molecules into ions and then separates the ions according to their mass-to-charge ratio, which allows identifying atoms and isotopes. The scientists can identify the structure of initial substance using the obtained mass spectra, existing mass spectra data base, and special software.
Finally, it is necessary to recreate the original mixture composition. This process can be compared with doing a puzzle, where a picture needs to be assembled from separate pieces. In the chemical analysis, the number of pieces and pictures is never known by analyst, so, it is a rather complicated task. Information to be processed is contained in the mass spectra of components of studied mixture.
Dr. Sobolevsky, colleague of Dr. Revel’sky, has explained us the applicability of their method. It allows detecting a wide range of substances, which can be used in food quality control and for research purposes. Actually, this method has an exceptional sensitivity and selectivity. It gives a unique possibility for studying the composition of different cell components. Particularly, the scientists have revealed significant differences between the composition of amino acids in a cell culture of adenocarcinoma of human colon and their composition in healthy cells of connective tissue. We continue our research now, but it is clear already that a cancerous cell can be distinguished from a healthy cell by the composition of amino acids. This promises a great breakthrough in cancer diagnostics.
Sergey Komarov | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
Layered 2D material improves efficiency for solar cells and LEDs
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...