Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Analysis To Identify Cancer

18.10.2004


An amazingly sensitive method for selective analysis of amino acids, sugars, fatty acids, and other vital compounds has been developed by Russian scientists. This method allows determining even their trace quantities (fractions of nanograms). It is applicable in identifying cancerous cells and diagnostics of cancer at the earliest stage, when traditional diagnostics fail to catch sight of the disease.

Dr. Igor Revel’sky and his colleagues from the Moscow State University have developed method that provides a 100-times increased sensitivity of detecting amino acids and other vital compounds, i.e., a highest precision of their detection. This can be used in controlling the quality of drugs and foods and, prospectively, may become an effective technique of cancer diagnostics that will be more reliable than traditional histology.

The Russian scientists propose to begin with the separation of a complex mixture (e.g., the contents of a cell suspected of cancer). They separate firstly water-soluble substances from the rest of the mixture and, then, treat each of the two obtained fractions with specific reagents. As a result, the analyzed substances become volatile and separable with the use of a gas chromatograph, in which they are diffused along with a carrier gas through a liquid or solid adsorbent for differential adsorption. Each component produces its own peak in chromatogram.



The next challenge is identifying the components and their concentrations. This is rather difficult, as investigated samples contain a great variety of components, and a universal type of detector with a high sensitivity is needed. Such a detector chosen by the Russian scientists is a mass spectrometer. This apparatus is rather expensive and requires special operation skills. It converts molecules into ions and then separates the ions according to their mass-to-charge ratio, which allows identifying atoms and isotopes. The scientists can identify the structure of initial substance using the obtained mass spectra, existing mass spectra data base, and special software.
Finally, it is necessary to recreate the original mixture composition. This process can be compared with doing a puzzle, where a picture needs to be assembled from separate pieces. In the chemical analysis, the number of pieces and pictures is never known by analyst, so, it is a rather complicated task. Information to be processed is contained in the mass spectra of components of studied mixture.

Dr. Sobolevsky, colleague of Dr. Revel’sky, has explained us the applicability of their method. It allows detecting a wide range of substances, which can be used in food quality control and for research purposes. Actually, this method has an exceptional sensitivity and selectivity. It gives a unique possibility for studying the composition of different cell components. Particularly, the scientists have revealed significant differences between the composition of amino acids in a cell culture of adenocarcinoma of human colon and their composition in healthy cells of connective tissue. We continue our research now, but it is clear already that a cancerous cell can be distinguished from a healthy cell by the composition of amino acids. This promises a great breakthrough in cancer diagnostics.

Sergey Komarov | alfa
Further information:
http://www.informnauka.ru

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>