Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Animal research suggests benefits of low-dose estrogen therapy

11.10.2004


Research in monkeys found that low-dose estrogen therapy significantly reduced the progression of fatty buildup in the arteries leading to the heart, according to research at Wake Forest University Baptist Medical Center, reported today at the annual meeting of the North American Menopause Society in Washington, D.C.

"We’ve shown that you can get the same reduction in coronary artery atherosclerosis with standard-dose or low-dose estrogen," said Thomas B. Clarkson, D.V.M., one of the investigators. "It is very significant."

The findings mirror a recent study in women, said Clarkson and Susan E. Appt, D.V.M., principal investigators of the animal study. Pharmaceutical companies are already marketing lower doses of the drug.



The monkey study looked at whether 0.3 milligrams per day of oral conjugated equine estrogen (CEE) would be as effective at reducing progression of atherosclerosis as the traditional oral dose of 0.625 milligrams per day (found in Premarin). Two groups of postmenopausal monkeys were fed a moderately fatty diet for 10 months – similar to the typical human diet – to induce the buildup of fat deposits in the arteries. For two years, the monkeys were then given the human equivalent of low-dose CEE or no estrogen.

Evaluation of the three main arteries leading to the heart showed that monkeys that were treated with estrogen had 55 percent less atherosclerosis than the monkeys that didn’t receive estrogen. This is similar to the results previously obtained in monkeys who received the traditional dose of estrogen.

The monkeys were selected to be equivalent to women during the early postmenopausal years. "This study suggests that low-dose estrogen may be as effective at inhibiting atherosclerosis as the traditional dose in early postmenopausal subjects," said Clarkson, professor of comparative medicine.

Clarkson said the findings are important because they suggest that women who are taking low-dose estrogen for their menopausal symptoms may also benefit from a heart disease perspective. Several studies are evaluating the low-dose therapy in women.

A recent study by Kwang Kon Koh at Hokkaido University Graduate School of Medicine in Japan, compared women who received low-dose and standard-dose estrogen – in combination with the hormone progestin – for two months. The researchers found that the two doses had comparable favorable effects on several markers of cardiovascular health, including cholesterol concentrations and artery flexibility. In addition, the lower doses were less likely to result in changes that increase the risk of blot clot formation, which can lead to heart attacks and stroke.

The Kronos Longevity Research Institute is funding a five-year study of women ages 45 to 54. The study will recruit 900 women to evaluate an oral tablet containing low-dose estrogen, a skin patch delivering estrogen or a placebo. At the end of the five years, researchers will use ultrasound to evaluate the thickness of artery walls. Thickened artery walls are a sign of early atherosclerosis.

Also involved in the Wake Forest Baptist research was Mary Anthony, Ph.D., who was at Wake Forest Baptist at the time the research took place.

Karen Richardson | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Life Sciences:

nachricht The irresistible fragrance of dying vinegar flies
16.08.2017 | Max-Planck-Institut für chemische Ökologie

nachricht How protein islands form
15.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

Im Focus: Scientists improve forecast of increasing hazard on Ecuadorian volcano

Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).

The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

New thruster design increases efficiency for future spaceflight

16.08.2017 | Physics and Astronomy

Transporting spin: A graphene and boron nitride heterostructure creates large spin signals

16.08.2017 | Materials Sciences

A new method for the 3-D printing of living tissues

16.08.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>