Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Animal research suggests benefits of low-dose estrogen therapy

11.10.2004


Research in monkeys found that low-dose estrogen therapy significantly reduced the progression of fatty buildup in the arteries leading to the heart, according to research at Wake Forest University Baptist Medical Center, reported today at the annual meeting of the North American Menopause Society in Washington, D.C.

"We’ve shown that you can get the same reduction in coronary artery atherosclerosis with standard-dose or low-dose estrogen," said Thomas B. Clarkson, D.V.M., one of the investigators. "It is very significant."

The findings mirror a recent study in women, said Clarkson and Susan E. Appt, D.V.M., principal investigators of the animal study. Pharmaceutical companies are already marketing lower doses of the drug.



The monkey study looked at whether 0.3 milligrams per day of oral conjugated equine estrogen (CEE) would be as effective at reducing progression of atherosclerosis as the traditional oral dose of 0.625 milligrams per day (found in Premarin). Two groups of postmenopausal monkeys were fed a moderately fatty diet for 10 months – similar to the typical human diet – to induce the buildup of fat deposits in the arteries. For two years, the monkeys were then given the human equivalent of low-dose CEE or no estrogen.

Evaluation of the three main arteries leading to the heart showed that monkeys that were treated with estrogen had 55 percent less atherosclerosis than the monkeys that didn’t receive estrogen. This is similar to the results previously obtained in monkeys who received the traditional dose of estrogen.

The monkeys were selected to be equivalent to women during the early postmenopausal years. "This study suggests that low-dose estrogen may be as effective at inhibiting atherosclerosis as the traditional dose in early postmenopausal subjects," said Clarkson, professor of comparative medicine.

Clarkson said the findings are important because they suggest that women who are taking low-dose estrogen for their menopausal symptoms may also benefit from a heart disease perspective. Several studies are evaluating the low-dose therapy in women.

A recent study by Kwang Kon Koh at Hokkaido University Graduate School of Medicine in Japan, compared women who received low-dose and standard-dose estrogen – in combination with the hormone progestin – for two months. The researchers found that the two doses had comparable favorable effects on several markers of cardiovascular health, including cholesterol concentrations and artery flexibility. In addition, the lower doses were less likely to result in changes that increase the risk of blot clot formation, which can lead to heart attacks and stroke.

The Kronos Longevity Research Institute is funding a five-year study of women ages 45 to 54. The study will recruit 900 women to evaluate an oral tablet containing low-dose estrogen, a skin patch delivering estrogen or a placebo. At the end of the five years, researchers will use ultrasound to evaluate the thickness of artery walls. Thickened artery walls are a sign of early atherosclerosis.

Also involved in the Wake Forest Baptist research was Mary Anthony, Ph.D., who was at Wake Forest Baptist at the time the research took place.

Karen Richardson | EurekAlert!
Further information:
http://www.wfubmc.edu

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>