Research at the Sir William Dunn School of Pathology has identified Dectin-1 as the beta-glucan receptor on immune cells. This finding may be of use in the prophylactic prevention of a variety of infections, especially in surgical patients, and in the treatment of cancer. The identification of Dectin-1 as the beta-glucan receptor may also provide a novel strategy for combating fungal infections.
b-Glucans are glucose polymers which possess immunomodulatory activities, although until our invention, it was unclear how these carbohydrates mediate their effects. We have identified Dectin-1 as the major cellular receptor involved in the recognition and response to beta-glucans. The receptor is expressed on a variety of immune cells, including macrophages and neutrophils, which play a central role in the immune and inflammatory responses and provide the first line of defence against infections. The recognition of beta-glucan by Dectin-1 leads to cellular activation a proinflammatory response, and essential requirement for controlling infection. This invention will allow research into using the properties of Dectin-1 for the prevention and control of disease, as described above.
This invention comprises the identification of Dectin-1 as the beta-glucan receptor. This invention will allow research into the therapeutic potential of targets to this receptor.
Kim Bruty | alfa
A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau
On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung
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