Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Yale scientists find cooperative RNA switches in nature

08.10.2004


Research at Yale reported in the journal Science identifies a new riboswitch (RNA regulatory sequence) class in bacteria that operates as a rare "ON" switch for genetic regulation of the three proteins in a glycine processing system.



"This seems like something only a biochemist can appreciate, but what it really means is that modern RNA has what it takes to run the complex metabolism of life. It is like what would have been needed in an "RNA World" - or a period in evolution where RNA served a much larger role," said Ronald T. Breaker, professor in the Department of Molecular, Cellular and Developmental Biology at Yale University.

The latest riboswitch is unique because it is the first RNA switch known to have "cooperative binding" to its target, a process that is common in protein enzymes but not usually associated with RNA. It is also surprising that such complex relics of an RNA World are seen in modern organisms.


Breaker and his research team have pioneered the field of riboswitches and reported the existence of nine classes, so far. Earlier this year they reported in the journal Nature on a class of riboswitch that are ribozymes and catalyze their own feedback loop. The work received the highest all time rating of a peer-reviewed scientific paper by the Faculty of 1000, an on-line web resource where top researcher from around the world rank scientific publications

Breaker’s research, testing theories about how life began, led to the synthesis of "RNA switches" that respond to various target compounds, including several molecules of basic metabolism. They speculated that, if an RNA World theory were true, then RNA molecules most likely would make great molecular switches. After creating RNA switches in the lab, including using a process that simulates Darwinian evolution in the test tube, they looked for naturally occurring riboswitches.

Other authors on this paper include Maumita Mandall, Mark Lee, Jeffrey Barrick and Gail Mitchell Emilsson from Yale and Zasha Weinberg and Walter L. Russo from the University of Washington. The work was supported by grants from the National Institutes of Health, the National Science Foundation, the Yale Liver Center and the David and Lucille Packard Foundation.

Janet Rettig Emanuel | EurekAlert!
Further information:
http://www.yale.edu

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>