Researchers from The Rockefeller University have uncovered specific mechanisms by which cells that are genetically programmed to commit suicide stimulate growth in surrounding cells. The research, published online in Developmental Cell, provides new information about how normal, healthy tissues are maintained and may shed some light on a pathway that may contribute to tumor growth.
It has been known for some time that cells that die as a result of injury-provoked programmed cell death, also known as apoptosis, may stimulate the growth of surrounding cells. "Such compensatory mechanisms may be essential to allow for the elimination of as many damaged or dangerous cells as needed without compromising organismal fitness. In spite of its importance, the underlying mechanisms are poorly understood," explains study leader Dr. Hermann Steller.
Dr. Steller and colleagues demonstrate that when cells from the imaginal disc in the fruit fly Drosophila are stimulated to undergo apoptosis but experimentally manipulated so that they do not actually die ("undead cells"), they stimulate the growth of neighboring tissue. The researchers demonstrate that the undead cells promote cell growth in the surrounding imaginal disc by activating specific signaling cascades that are known to be required for cell proliferation. Although artificial, the experimental creation of undead cells allows this phenomenon to be expanded and studied. The authors provide evidence that apoptotic cells that are allowed to complete the process of dying also secrete the growth-stimulating signals.
Heidi Hardman | EurekAlert!
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Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
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In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
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