Researchers from The Rockefeller University have uncovered specific mechanisms by which cells that are genetically programmed to commit suicide stimulate growth in surrounding cells. The research, published online in Developmental Cell, provides new information about how normal, healthy tissues are maintained and may shed some light on a pathway that may contribute to tumor growth.
It has been known for some time that cells that die as a result of injury-provoked programmed cell death, also known as apoptosis, may stimulate the growth of surrounding cells. "Such compensatory mechanisms may be essential to allow for the elimination of as many damaged or dangerous cells as needed without compromising organismal fitness. In spite of its importance, the underlying mechanisms are poorly understood," explains study leader Dr. Hermann Steller.
Dr. Steller and colleagues demonstrate that when cells from the imaginal disc in the fruit fly Drosophila are stimulated to undergo apoptosis but experimentally manipulated so that they do not actually die ("undead cells"), they stimulate the growth of neighboring tissue. The researchers demonstrate that the undead cells promote cell growth in the surrounding imaginal disc by activating specific signaling cascades that are known to be required for cell proliferation. Although artificial, the experimental creation of undead cells allows this phenomenon to be expanded and studied. The authors provide evidence that apoptotic cells that are allowed to complete the process of dying also secrete the growth-stimulating signals.
Heidi Hardman | EurekAlert!
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Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.
The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
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In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
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