Researchers at The University of Texas M. D. Anderson Cancer Center have figured out a key molecular step by which a cancer cell can unhook itself from the mesh weave of other cancer cells in a tumor, and move away to a different part of the body - the process, known as metastasis, that makes cancer so dangerous.
Describing what they call a critical "molecular switch" - detailed in the advance online edition of the journal Nature Cell Biology - the researchers say the door is now open to designing new ways to block that metastasis. "It always has been a mystery as to what allows a cancer cell to become mobile and move away from a tumor, but now we have found a very interesting mechanism that explains it," says the studys lead author, Mien-Chie Hung, Ph.D., a professor and chair of the Department of Molecular and Cellular Oncology. That switch, in the form of an enzyme known as GSK-3ß, which is known to alter the function of proteins, may "offer us an anticancer strategy to pursue," Hung says.
Most cancers are of the "solid tumor" variety, and are made up of epithelial cells - those which make up the membranous tissue covering organs and other internal surfaces of the body. Although epithelial cells are firmly fixed to each other in a network that makes up tissue, researchers know from the study of developmental biology that embryonic epithelial cells have the ability to move. To do that, epithelial cells take on the characteristics of what are known as "mesenchymal" cells, those that develop into connective tissue and blood vessel cells, among other tissue types. They are capable of forming collagen fibers that allows them to "creep along" to where they are needed during development.
Nancy Jensen | EurekAlert!
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Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.
The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
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In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
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