Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Molecular switch found that allows cancer cells to become mobile

28.09.2004


Researchers at The University of Texas M. D. Anderson Cancer Center have figured out a key molecular step by which a cancer cell can unhook itself from the mesh weave of other cancer cells in a tumor, and move away to a different part of the body - the process, known as metastasis, that makes cancer so dangerous.



Describing what they call a critical "molecular switch" - detailed in the advance online edition of the journal Nature Cell Biology - the researchers say the door is now open to designing new ways to block that metastasis. "It always has been a mystery as to what allows a cancer cell to become mobile and move away from a tumor, but now we have found a very interesting mechanism that explains it," says the study’s lead author, Mien-Chie Hung, Ph.D., a professor and chair of the Department of Molecular and Cellular Oncology. That switch, in the form of an enzyme known as GSK-3ß, which is known to alter the function of proteins, may "offer us an anticancer strategy to pursue," Hung says.

Most cancers are of the "solid tumor" variety, and are made up of epithelial cells - those which make up the membranous tissue covering organs and other internal surfaces of the body. Although epithelial cells are firmly fixed to each other in a network that makes up tissue, researchers know from the study of developmental biology that embryonic epithelial cells have the ability to move. To do that, epithelial cells take on the characteristics of what are known as "mesenchymal" cells, those that develop into connective tissue and blood vessel cells, among other tissue types. They are capable of forming collagen fibers that allows them to "creep along" to where they are needed during development.


This process, known as "epithelial-mesenchymal transition (EMT)," has recently been observed in cancer progression, Hung says. "It was discovered that the increased motility and invasiveness of cancer cells resembles the EMT that occurs during embryonic development," he says. "And since about 90 percent of cancer deaths result from local invasion and distant metastasis of tumor cells, an insight into how this process works in cancer has been urgently needed."

Some of this transition process in cancer cells already has been described, Hung says. What has been known is that epithelial cells have a lot of protein known as E-cadherin, which act like anchors, fixing the cells onto the tissue membrane while gluing cells to each other. In contrast, mesenchymal cells do not "express" E-cadherin, which allows them to move freely.

Another piece of the puzzle was already in place: a transcription factor known as "snail" was found to control the gene that produces the E-cadherin protein. Snail turns off E-cadherin expression, thus freeing epithelial cell from its tethers. So the question Hung and his research team explored is: what regulates snail? What "tells" snail to turn off E-cadherin? "Cells without E-cadherin are not stuck to each other any more and can move, so we looked for the regulator of snail," Hung says.

Through a series of experiments, they found that the GSK-3ß enzyme controls snail. It does this by directing snail out of the cell’s nucleus (where proteins are located) and into the cell’s cytoplasm, where it is then degraded. "This enzyme tells the snail transcription factor to go to the wrong place, where it is then destroyed," Hung says.

So when GSK-3ß controls the action of snail, a cancer cell continues to produce E-cadherin and retains all the properties of a fixed epithelial cell, the researchers discovered. Tumor cells in which GSK-3ß activity is repressed become unanchored, Hung says, suggesting that a therapy that bolsters GSK-3ß may repress the ability of cancer to spread.

Hung and his group also say that known cancer pathways, such as those that involve the epidermal growth factor receptor (EGFR) have been shown to inhibit the GSK-3ß enzyme. "So this all makes sense. We have mechanistically shown how a signaling pathway known to promote cancer development can also promote metastasis," he says. "Now we have to work on ways to inhibit that process."

Nancy Jensen | EurekAlert!
Further information:
http://www.mdanderson.org

More articles from Life Sciences:

nachricht Cancer diagnosis: no more needles?
25.05.2018 | Christian-Albrechts-Universität zu Kiel

nachricht Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>