When cells express the abnormal protein… In these cells, the blue, green and yellow labeling respectively corresponds to the nucleus, the abnormal protein EWS/FLI-1 and the protein IGFBP-3. In the cells where EWS/FLI-1 is present (green labeling), IGFBP-3 is absent (no yellow labeling), confirming that EWS/FLI1 prevents expression of the IGFBP-3 gene. A. Prieur/Institut Curie
To develop new therapeutic approaches to cancer, it is essential to understand the long and extremely complex process that underlies it, in other words the various stages of cancer development from the initial mutation to the tumor. Having already identified the alteration that leads to Ewing’s sarcoma, a bone cancer which afflicts young people, an Inserm team at the Institut Curie has recently used a combination of novel techniques to show that there 86 deregulated genes in these tumors. One of these genes, a new “link” in the development of Ewing’s sarcoma, could be used as a therapeutic target. These discoveries were published in the August 2004 issue of Molecular and Cellular Biology.
Cancer results from the proliferation of abnormal cells in the body. The trigger is an alteration in the genetic material of a single cell, in certain genes that regulate vital processes (division, differentiation, apoptosis, repair). However, a single mutation is not enough to transform a health cell into a cancer cell. Rather it is a succession of genetic accidents that results in uncontrolled cells that accumulate and lead to tumor formation.
Few cancers have a simple molecular signature – a specific mutation that leads to tumor growth. In Ewing’s sarcoma, a malignant tumor of the bone which affects children, teenagers and young adults, this molecular signature has been discovered thanks to a close collaboration between physicians and researchers at the Institut Curie, the internationally renowned reference center for the study and treatment of Ewing’s sarcoma.
One step closer to reality
20.04.2018 | Max-Planck-Institut für Entwicklungsbiologie
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University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
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Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
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20.04.2018 | Physics and Astronomy