When cells express the abnormal protein… In these cells, the blue, green and yellow labeling respectively corresponds to the nucleus, the abnormal protein EWS/FLI-1 and the protein IGFBP-3. In the cells where EWS/FLI-1 is present (green labeling), IGFBP-3 is absent (no yellow labeling), confirming that EWS/FLI1 prevents expression of the IGFBP-3 gene. A. Prieur/Institut Curie
To develop new therapeutic approaches to cancer, it is essential to understand the long and extremely complex process that underlies it, in other words the various stages of cancer development from the initial mutation to the tumor. Having already identified the alteration that leads to Ewing’s sarcoma, a bone cancer which afflicts young people, an Inserm team at the Institut Curie has recently used a combination of novel techniques to show that there 86 deregulated genes in these tumors. One of these genes, a new “link” in the development of Ewing’s sarcoma, could be used as a therapeutic target. These discoveries were published in the August 2004 issue of Molecular and Cellular Biology.
Cancer results from the proliferation of abnormal cells in the body. The trigger is an alteration in the genetic material of a single cell, in certain genes that regulate vital processes (division, differentiation, apoptosis, repair). However, a single mutation is not enough to transform a health cell into a cancer cell. Rather it is a succession of genetic accidents that results in uncontrolled cells that accumulate and lead to tumor formation.
Few cancers have a simple molecular signature – a specific mutation that leads to tumor growth. In Ewing’s sarcoma, a malignant tumor of the bone which affects children, teenagers and young adults, this molecular signature has been discovered thanks to a close collaboration between physicians and researchers at the Institut Curie, the internationally renowned reference center for the study and treatment of Ewing’s sarcoma.
Meadows beat out shrubs when it comes to storing carbon
23.11.2017 | Norwegian University of Science and Technology
Migrating Cells: Folds in the cell membrane supply material for necessary blebs
23.11.2017 | Westfälische Wilhelms-Universität Münster
Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
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