Researchers at The University of Texas M. D. Anderson Cancer Center now have evidence that receptors found on tumors that were believed to function only on the surface of cells can actually switch on genes inside a cells nucleus, thus promoting cancer development in two distinct ways.
They specifically found that HER-2 cell surface receptors, known to promote breast and other cancers when they allow too many growth signals to enter a cell, can actually travel into the nucleus and turn on a variety of genes, including COX-2, which also is associated with carcinogenesis.
The discovery, published in the September issue of the journal Cancer Cell, likely will revolutionize the way scientists think about membrane receptors, says the studys lead author, Mien-Chie Hung, Ph.D., a professor in the Department of Molecular & Cellular Oncology. "For a number of years, researchers have found membrane receptors associated with cancer development in the nucleus of cells, but they believed these were just debris left over from the receptors primary job, which is to shuttle signals into a cell," says Hung. "Here we find that a receptor protein known to be important in one cancer pathway also can enter a cells nucleus to turn on genes associated with a different carcinogenesis pathway," he says. "Proof of the dual nature of these receptors may well change the nature of research associated with them and, possibly, treatment strategy."
Heather Sessions | EurekAlert!
One step closer to reality
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University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
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Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
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In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
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20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy