Researchers have combined sophisticated biochemical and imaging techniques to get a glimpse of the stepwise assembly of amyloid fibers in a yeast prion protein. Their findings suggest that these structured fibers form in competition with the amorphous globules that some believe may cause toxicity in amyloid diseases such as Alzheimers and Parkinsons. The researchers say this may have important implications for those designing drugs to prevent formation of the brain-damaging proteins in those diseases.
The researchers reported their findings in the October 2004 issue of the Public Library of Science Biology. They were led by Howard Hughes Medical Institute investigator Jonathan S. Weissman at the University of California, San Francisco. HHMI investigator Ronald D. Vale, also of UCSF, was a co-author of the article.
Working in yeast, Weissman and his colleagues investigated the mechanism by which a prion protein assembles individual polypeptides into long amyloid fibers. These fibers are similar to the amyloid plaques that clog the brains of patients with Alzheimers or Parkinsons disease.
Jennifer Michalowski | EurekAlert!
New application for acoustics helps estimate marine life populations
16.01.2018 | University of California - San Diego
Unexpected environmental source of methane discovered
16.01.2018 | University of Washington Health Sciences/UW Medicine
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
17.01.2018 | Ecology, The Environment and Conservation
17.01.2018 | Physics and Astronomy
17.01.2018 | Awards Funding