Mayo Clinic researchers have used a comparative genomic strategy to demonstrate a causative link between eosinophils, a rare type of white blood cell, and asthma. Their research shows that the presence of these unique blood cells is absolutely required for the development of asthma. The details of this animal-based study appear in the Sept. 17, 2004, issue of Science, the journal of the American Association for the Advancement of Science (AAAS).
For more than a century, scientists have known that eosinophils are often the dominant inflammatory cells present in the lungs of asthma patients, but the importance of these white blood cells has been poorly understood with some studies even discounting a role for these cells. This new study demonstrates that eosinophils are required for the mucus accumulation and the lung dysfunction associated with asthma.
Using the tools of genomics, Mayo Clinic researchers have engineered a mouse that is specifically devoid of eosinophils, but otherwise has a full complement of blood-derived cells. Disease symptoms in these transgenic mice were dramatically reduced, and in some cases completely eliminated, following exposure to an allergen that in normal animals leads to asthma.
Bob Nellis | EurekAlert!
Transport of molecular motors into cilia
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Asian dust providing key nutrients for California's giant sequoias
28.03.2017 | University of California - Riverside
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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