A genetically engineered mighty mouse is helping Medical College of Georgia researchers find the best way for young people to build bone and avoid osteoporosis.
"We are interested in kids; we want to know how to maximize their bone during peak periods of growth while they still can," says Dr. Mark Hamrick, bone biologist. "One of the best predictors of who is going to get osteoporosis and who is not is how much bone you have at sexual maturity. So we want to know what people can do from zero to age 18 that really is going to pack that bone on." These mighty mice, with up to 70 percent more muscle mass than a regular mouse and essentially no body fat, and a $1 million grant from the National Institutes of Health are helping Dr. Hamrick answer that question. The mice lack the myostatin gene, a negative regulator of muscle mass. "Lots of genes control muscle development," says Dr. Hamrick. "This one is pretty significant in terms of not letting muscles get too big."
Myostatin is expressed at highest levels during development, when the embryo is growing, to ensure that muscles dont overgrow, Dr. Hamrick says. The level expressed changes naturally over the course of life. "Its still expressed as children grow and is present in very low levels in adults," he says. "Its suggested that you might get rises in myostatin levels with aging, which is associated with a loss of muscle mass that typically accompanies increased age. " Some muscle-wasting diseases as well as space flight and extended bed rest also are associated with increased myostatin levels. Numerous products claim to help adults build muscle by turning off this powerful muscle regulator produced by muscle cells, Dr. Hamrick says. But the only product scientifically proven to block myostatin is a monoclonal antibody now under study for its potential to treat muscular dystrophy, he says.
Toni Baker | EurekAlert!
Research team creates new possibilities for medicine and materials sciences
22.01.2018 | Humboldt-Universität zu Berlin
Saarland University bioinformaticians compute gene sequences inherited from each parent
22.01.2018 | Universität des Saarlandes
On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.
We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...
What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...
For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.
Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...
At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.
No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...
Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.
Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...
08.01.2018 | Event News
11.12.2017 | Event News
08.12.2017 | Event News
22.01.2018 | Materials Sciences
22.01.2018 | Earth Sciences
22.01.2018 | Life Sciences