Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers aim to create ’living glue’ for replacement joints

16.09.2004


By combining stem cell science with orthopedic surgery, a team of researchers at the University of British Columbia and Vancouver Coastal Health Research Institute aims to reduce the 10 per cent failure rate in hip replacements and make repeat replacements and other joint repairs obsolete within 10-15 years.



With $1.5 million over five years in funding from the Canadian Institutes for Health Research, a group of seven UBC scientists will explore how stem cells – the body’s "master cells" that can reproduce and develop many mature functional cells – can be used to regenerate bone cells to better secure artificial joints and other bone replacement structures. "We’re very excited about the potential for long-term success for patients who need repeat surgery to repair or replace bone," says Fabio Rossi, UBC assistant professor of medical genetics and Canada Research Chair in Regenerative Medicine. "By using a well-understood stem cell and available technologies, we can accelerate research and have our discoveries quickly incorporated into patient care."

The team will create a new fixative mixture that combines minerals and slow-release growth factors. The mixture will be seeded with the patient’s own mesenchymal stem cells – a type of stem cell that is easily extracted from adult bone marrow and capable of manufacturing bone cells and connective tissue. This "living glue" will form a strong, organic environment to secure artificial joints, vertebrae or other replacement structures where the original replacement has failed.


"Currently, these repeat replacements are difficult because considerable bone is lost as the joint gradually breaks down," says team member Tom Oxland, Canada Research Chair in Biomedical Engineering and director of The Centre for Hip Health, located at the Vancouver Coastal Health Research Institute (VCHRI). "New techniques will fill a critical need for the increasing number of people undergoing hip replacement and will also be useful for other bone loss patients." Hip fracture is one of the most common problems leading to bone loss and currently there is a 10 per cent failure rate in the 20,000 hip replacements performed annually in Canada. Problems include breakdown of the acrylic glue used to secure the prosthetic joint and weakened or damaged tissue surrounding the joint.

Team members include Don Brunette, associate dean, Research, Faculty of Dentistry; Pharmaceutical Sciences Prof. Helen Burt; Orthopedics Dept. Head Clive Duncan; Applied Science Assistant Prof. Goran Fernlund and Orthopedics Engineering post-doctoral fellow Hanspeter Frei.

Hilary Thomson | EurekAlert!
Further information:
http://www.ubc.ca

More articles from Life Sciences:

nachricht Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz

nachricht Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>