Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Picking prostanoids to provide protection


Roles of thromboxane A2 and prostacyclin in the development of atherosclerosis in apoE-deficient mice

Atherosclerosis is an inflammation in the lining of the arteries. Biological chemicals in the body called pros-tanoids, which are made from the breakdown of arachidonic acid by the action of an enzyme called COX have been implicated in the development of atherosclerosis. The role of prostanoids in inflammation is well known, based on studies of aspirin-like non-steroidal anti-inflammatory drugs, which act to inhibit the action of COX. Two prostenoids called PG I2/prostacyclin (PGI2) and thromboxane A2 (TXA2), are ele-vated in individuals with atheroscle-rosis, but their roles in the initiation and development of atherosclerosis remain ill-defined. To investigate the role of each of these prostanoids in atherosclerosis, Shuh Narumiya and colleagues, of Kyoto University Faculty of Medicine, have bred an ath-erosclerotic mouse model (apoE–/–) with mice that were deficient in either the PGI receptor (IP) or the TXA receptor (TP).

These mice allowed the authors to examine the effect of loss of PGI or TXA action on atherosclerosis development. Relative to apoE–/– mice, the apoE–/–IP–/– mice had accelerated initiation and development of athero-sclerosis, while the apoE–/–TP–/– mice had delayed development. apoE–/–IP–/– mice also demonstrated other mark-ers of more severe disease, compared with apoE–/– mice. apoE–/–TP–/– mice presented with fewer markers of dis-ease. These data indicate that PGI2 protects against and TXA2 promotes atherosclerosis development. The use of TP antagonists and molecules with PG-like activity may therefore aid in atherosclerosis prevention. Furthermore these data fit well with previous work that indicated that low doses of aspirin, which inhibits TXA2 more than PGI2, has been used as anti-platelet therapy for the prevention of myocardial infarction and recurrence of strokes.

Laurie Goodman | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht ‘Farming’ bacteria to boost growth in the oceans
24.10.2016 | Max-Planck-Institut für marine Mikrobiologie

nachricht Calcium Induces Chronic Lung Infections
24.10.2016 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Oasis of life in the ice-covered central Arctic

24.10.2016 | Earth Sciences

‘Farming’ bacteria to boost growth in the oceans

24.10.2016 | Life Sciences

Light-driven atomic rotations excite magnetic waves

24.10.2016 | Physics and Astronomy

More VideoLinks >>>