New research has shown, using human tissue biopsies - a hypothesis that until now could only be argued indirectly using cell cultures – that the significant increase in genomic "disorder" that is associated with breast cancer occurs in the transition between the typical hyperplasia and the in situ carcinoma, coinciding with a reduction to a critical minimum in the cell chromosome terminations (known as telomeres). This process of critical reduction, occurring due to the accumulation of cell divisions, causes problems in the cell division process, giving rise to cells with an abnormal genetic content. These cells are normally detected and eliminated from the organism thanks to a complex control and defence mechanism, but the activation of a protein known as telomerase is capable of short-circuiting these defence mechanisms and perpetuate these cells with abnormal genetic content, facilitating the development of the cancer.
The research work was carried out in the prestigious Lawrence Berkeley National Laboratory of the US Department of Energy at Berkeley (California) in collaboration with the University of California in San Francisco.
The contribution of the Spanish scientists Carlos Ortiz de Solórzano and Enrique García Rodríguez to the research was the development of programmes for the analysis of images from confocal 3D microscopy by which each cell can be observed separately and the amount of DNA in each cell nucleus determined. The number of de copies of genes involved in the development of the cancer and the number and length of the telomeres of these cells can be thus determined. This study would not have been possible without the 3D scientific visualisation programmes. The task group at the Lawrence Berkeley National Laboratory was directed by Dr. Carlos Ortiz de Solórzano, who leads a microscopy and biomedical image analysis group.
Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration
"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...
Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...
10.01.2017 | Event News
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16.01.2017 | Trade Fair News
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16.01.2017 | Life Sciences