Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Signal molecule holds possible key to tumour growth

07.09.2004


Immunity to a cancer in chickens could shed light on ways to control certain human cancers according to scientists from the Institute for Animal Health (IAH). Their work on Marek’s disease (MD) in chickens has identified the first natural model for specific Hodgkin’s and non-Hodgkin’s lymphomas, and is published this week in PNAS (06-10 September 2004).

Marek’s disease virus (MDV) shares many biological properties with Epstein-Barr virus (EBV) – a major cause of Hodgkin’s disease. Infection with these herpesviruses can lead to lymphoma formation, which is closely linked with the over-production of a cell-surface molecule called CD30.

“For the first time we have detected the presence of specific antibodies against CD30 after MDV infection in MD-resistant chickens,” says lead researcher Dr Shane Burgess, now at Mississippi State University, USA. “The presence of CD30-specific antibodies suggests anti-tumour immunity may exist in Marek’s disease, and perhaps also in some Hodgkin’s and non-Hodgkin’s lymphoma patients.”



CD30 promotes the survival of normal lymphocytes – essential for immune responses – and can also influence cell death. However, over-expression of CD30 is associated with the survival of lymphoma cells.

“We have shown that the chicken CD30 gene resembles the ancestral form of the human CD30 gene structure, and we have developed a new understanding for how this model has evolved in mammals, including humans” says Dr Fred Davison, Head of Avian Immunology at IAH. “CD30 over-expression is evolutionarily conserved, and we think that this molecule is part of a critical cell signalling pathway that is disturbed during the formation of many different lymphomas.”

Tracey Duncombe | alfa
Further information:
http://www.iah.bbsrc.ac.uk

More articles from Life Sciences:

nachricht Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel

nachricht The Nagoya Protocol Creates Disadvantages for Many Countries when Applied to Microorganisms
05.12.2016 | Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers uncover protein-based “cancer signature”

05.12.2016 | Life Sciences

The Nagoya Protocol Creates Disadvantages for Many Countries when Applied to Microorganisms

05.12.2016 | Life Sciences

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>