VeraChem LLC founders Drs. Michael Gilson, Michael Potter, and Hillary Gilson, using UMBI licensed intellectual property, are creating scientific software that provides expert users with tools for computer-aided drug discovery and molecular design. VeraChem’s recent first sale, a pre-release version of Vconf, is followed by the projected launch on September 8 of Vcharge, a new software product for computing molecular properties important in drug design. The official launch of Vconf is expected to follow later in 2004.
“Vcharge combines speed and accuracy in a unique software package that will be available for the Linux and Windows operating systems,” says Dr. Gilson, Chief Scientific Officer for VeraChem LLC and Professor at UMBI’s Center for Advanced Research in Biotechnology. “This product is just the first in a series that will bring advanced computational methods in an affordable and user-friendly format to experts in the pharmaceutical and biotechnology industries.”
“Vcharge is a tool for computer-aided drug design,” says Dr. Gilson. “It allows the designer to compute the atomic charges of a candidate drug molecule as a step in determining whether it will effectively bind a targeted protein. Most drugs work by binding tightly to a targeted protein molecule. For example, HIV protease inhibitors help patients by binding and blocking the function of a protein that the AIDS virus needs to survive and reproduce. Each atom of a protein carries a small electrical charge and, since opposite charges attract while like charges repel, it is important that the atoms of a drug molecule have charges which complement the targeted protein.”
The dark side of cichlid fish: from cannibal to caregiver
20.04.2018 | Veterinärmedizinische Universität Wien
Enduring cold temperatures alters fat cell epigenetics
19.04.2018 | University of Tokyo
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
In an article that appears in the journal “Review of Modern Physics”, researchers at the Laboratory for Attosecond Physics (LAP) assess the current state of the field of ultrafast physics and consider its implications for future technologies.
Physicists can now control light in both time and space with hitherto unimagined precision. This is particularly true for the ability to generate ultrashort...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
19.04.2018 | Materials Sciences
19.04.2018 | Physics and Astronomy
19.04.2018 | Physics and Astronomy