Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bone marrow cells routinely help with wound healing

03.09.2004


’Wounds may not heal the way we thought they did’

Bone marrow produces cells that not only help fight infection, but also permanently heal wounds, according to research at the University of Washington. Previously, researchers had not known that bone marrow contributed to the development of new skin in wounds. The findings will be published in the Sept. 3 issue of Stem Cells.

"Wounds may not heal the way we thought they did," says Dr. Richard Ikeda, a biochemist at the National Institute of General Medical Sciences, one of the National Institutes of Health, which supported the work. "This study shows that bone marrow stem cells, in addition to cells from the surrounding tissue, may actually contribute to the healing process. If this is the case, it could lead to completely new ways of treating serious wounds."



When a body is wounded, the body immediately tries to form a clot in order to stop the bleeding. The seal is formed with the help of cells that circulate in your blood all the time and are on the spot immediately. The body also has an inflammatory response: signals direct white blood cells to the area of the wound. The white blood cells arrive to fight off foreign bacteria and infection. This inflammatory response is responsible for the red area around a wound. The inflammatory response goes away within a few days to a week, assuming there is no continued infection.

"Scientists have long assumed that once the inflammatory response concludes, the white blood cells mostly either then die or go into circulation in the bloodstream. We did not know, until now, that the bone marrow-derived cells go on to become a significant part of the new skin," said Dr. Frank Isik, professor of surgery at the University of Washington. "We’ve known that bone marrow cells are involved in wound healing and inflammation – now we have data that shows bone marrow cells are involved in normal skin maintenance, in maintaining the matrix environment and integrity of the skin."

Bone marrow has been studied for a number of purposes in recent years because it is rich in stem cells – cells that can go on to become many different kinds of cells. In order to conduct this research, Isik and colleagues obtained a strain of mice whose bodies glow green under fluorescent light. The researchers removed bone marrow from the mice and then performed a stem cell transplant into a genetically identical strain of normal mice, whose cells do not glow green. Afterward, only the bone marrow of the transplanted mice glowed green inside the bodies of the mice, allowing researchers to track the bone marrow cells throughout the body. Researchers found green cells throughout the body, but observed that the highest concentration of bone marrow cells was in normal skin.

That was a surprise. People have known for awhile that there are a few white blood cells in the skin – that’s how people come down with contact dermatitis. Contact dermatitis happens when someone develops an inflammatory reaction to a substance that touches his or her skin. However, the white blood cells involved in contact dermatitis express a certain protein, CD45. The new cells identified in the transplanted mice did not produce that protein, and do not seem to be implicated in contact dermatitis. Researchers found that even after six weeks, long after the infection-fighting role seems to be over, the bone marrow-derived cells cluster within the healing area of a wound.

The researchers ran these skin cells through a flow cytometer to separate them into green and non-green fractions and found only the green cells in the skin produced collagen type III, which is one of the two most abundant collagens in skin. The native skin cells produced only collagen type I. Researchers do not know why bone marrow would produce collagen III, which is typically found in connective tissues such as skin.

"What we have here is a new cell population that was not previously recognized," Isik said. "The bone marrow cells help form the matrix of the skin. Collagen is what gives your skin its tough nature. It’s expandable, and it’s tough. You cannot break your skin without a sharp object. The reason is because of the collagen content, a scaffolding that is very strong."

Walter Neary | EurekAlert!
Further information:
http://www.u.washington.edu

More articles from Life Sciences:

nachricht Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz

nachricht Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>