Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bone marrow cells routinely help with wound healing

03.09.2004


’Wounds may not heal the way we thought they did’

Bone marrow produces cells that not only help fight infection, but also permanently heal wounds, according to research at the University of Washington. Previously, researchers had not known that bone marrow contributed to the development of new skin in wounds. The findings will be published in the Sept. 3 issue of Stem Cells.

"Wounds may not heal the way we thought they did," says Dr. Richard Ikeda, a biochemist at the National Institute of General Medical Sciences, one of the National Institutes of Health, which supported the work. "This study shows that bone marrow stem cells, in addition to cells from the surrounding tissue, may actually contribute to the healing process. If this is the case, it could lead to completely new ways of treating serious wounds."



When a body is wounded, the body immediately tries to form a clot in order to stop the bleeding. The seal is formed with the help of cells that circulate in your blood all the time and are on the spot immediately. The body also has an inflammatory response: signals direct white blood cells to the area of the wound. The white blood cells arrive to fight off foreign bacteria and infection. This inflammatory response is responsible for the red area around a wound. The inflammatory response goes away within a few days to a week, assuming there is no continued infection.

"Scientists have long assumed that once the inflammatory response concludes, the white blood cells mostly either then die or go into circulation in the bloodstream. We did not know, until now, that the bone marrow-derived cells go on to become a significant part of the new skin," said Dr. Frank Isik, professor of surgery at the University of Washington. "We’ve known that bone marrow cells are involved in wound healing and inflammation – now we have data that shows bone marrow cells are involved in normal skin maintenance, in maintaining the matrix environment and integrity of the skin."

Bone marrow has been studied for a number of purposes in recent years because it is rich in stem cells – cells that can go on to become many different kinds of cells. In order to conduct this research, Isik and colleagues obtained a strain of mice whose bodies glow green under fluorescent light. The researchers removed bone marrow from the mice and then performed a stem cell transplant into a genetically identical strain of normal mice, whose cells do not glow green. Afterward, only the bone marrow of the transplanted mice glowed green inside the bodies of the mice, allowing researchers to track the bone marrow cells throughout the body. Researchers found green cells throughout the body, but observed that the highest concentration of bone marrow cells was in normal skin.

That was a surprise. People have known for awhile that there are a few white blood cells in the skin – that’s how people come down with contact dermatitis. Contact dermatitis happens when someone develops an inflammatory reaction to a substance that touches his or her skin. However, the white blood cells involved in contact dermatitis express a certain protein, CD45. The new cells identified in the transplanted mice did not produce that protein, and do not seem to be implicated in contact dermatitis. Researchers found that even after six weeks, long after the infection-fighting role seems to be over, the bone marrow-derived cells cluster within the healing area of a wound.

The researchers ran these skin cells through a flow cytometer to separate them into green and non-green fractions and found only the green cells in the skin produced collagen type III, which is one of the two most abundant collagens in skin. The native skin cells produced only collagen type I. Researchers do not know why bone marrow would produce collagen III, which is typically found in connective tissues such as skin.

"What we have here is a new cell population that was not previously recognized," Isik said. "The bone marrow cells help form the matrix of the skin. Collagen is what gives your skin its tough nature. It’s expandable, and it’s tough. You cannot break your skin without a sharp object. The reason is because of the collagen content, a scaffolding that is very strong."

Walter Neary | EurekAlert!
Further information:
http://www.u.washington.edu

More articles from Life Sciences:

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

nachricht CWRU researchers find a chemical solution to shrink digital data storage
22.06.2017 | Case Western Reserve University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

Im Focus: Optoelectronic Inline Measurement – Accurate to the Nanometer

Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.

New Manufacturing Technologies for New Products

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

A new technique isolates neuronal activity during memory consolidation

22.06.2017 | Life Sciences

Plant inspiration could lead to flexible electronics

22.06.2017 | Materials Sciences

A rhodium-based catalyst for making organosilicon using less precious metal

22.06.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>