Researchers at UT Southwestern Medical Center at Dallas have developed a small molecule that mimics the action of a key "death-promoting" protein in cells, a finding that could lead to more effective cancer therapies with fewer side effects.
In the Sept. 3 issue of the journal Science, the researchers report on this new compound and how it behaves like the cellular protein Smac, a molecule that lifts barriers to cell death. Dr. Xiaodong Wang, professor of biochemistry and one of the authors of the Science paper, discovered Smac in 2000. "Every cell in our body has a self-destruction apparatus that becomes activated when a cell needs to be terminated," Dr. Wang said. "The Smac protein is one component of this normal cell-suicide process, called apoptosis."
Apoptosis, for example, is required for the removal of webbing between the toes and fingers of a developing fetus, as well as for the elimination of surplus neurons during the development of the human brain.
Amanda Siegfried | EurekAlert!
Shrews shrink in winter and regrow in spring
24.10.2017 | Max-Planck-Institut für Ornithologie
'Y' a protein unicorn might matter in glaucoma
23.10.2017 | Georgia Institute of Technology
Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
23.10.2017 | Event News
17.10.2017 | Event News
10.10.2017 | Event News
24.10.2017 | Life Sciences
23.10.2017 | Life Sciences
23.10.2017 | Physics and Astronomy