Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chemical engineers discover filtration system to help biotech industry

20.08.2004


Chemical engineers at New Jersey Institute of Technology (NJIT) have developed a new filtration system to enable scientists and engineers to separate and purify two different kinds of proteins having relatively close molecular weight. Until now, doing such separations with membrane filtration was impossible. This research was reported in the June 20, 2004 issue of Biotechnology and Bioengineering.



"This is good news," said Kamalesh K. Sirkar, PhD, distinguished professor of chemical engineering and the project’s lead researcher. "To separate the good from the bad proteins is an important engineering breakthrough. We believe that pharmaceutical companies will immediately be able to put our research to work."

Before this invention, proteins had to differ five to six times in their molecular weight, before a scientist or engineer could separate them using a process called ultra-filtration. "Now using a new kind of membrane that we invented at NJIT, the proteins can have almost the same molecular weight," said Sirkar. The process also will be more cost-effective because the machines can run on a continuous basis.


"The reason we think this process will be important to the industry is because purification of protein is important to its end use," said Sirkar. Impure proteins can’t be used in any biopharmaceutical applications. However, when scientists in the past have gone to separate proteins and remove impurities by chromatography, costs have escalated.

NJIT has funded this research to date. The next step is to seek outside funding because more work needs to be done. "We know the process will work with a mixture of two proteins. But, Sirkar speculated, will it work if the mixtures contain three or four proteins? More questions include: can it be used on viruses or endotoxins –the outer coating of a particular type of bacteria? Will the process work with non-biological macromolecules such as dextran? "We think it can be used, but we don’t know," said Sirkar. "That’s why we are seeking additional funding to continue this research."

Sirkar, a noted expert in the membrane filtration processes and holder of more than 20 patents, has been a research professor at NJIT since 1992. He is now the NJIT Foundation Professor of Membrane Separations. Sirkar also directs the NJIT Center for Membrane Technologies. The long-time Bridgewater Township resident received a master’s degree and doctorate in chemical engineering from the University of Illinois (Urbana). Meredith Feins, PhD, a June 2004 graduate of NJIT’s doctoral program in chemical engineering, worked on this research in the laboratory. Feins grew up in Cedar Grove and now resides in River Vale.

Sheryl Weinstein | EurekAlert!
Further information:
http://www.njit.edu

More articles from Life Sciences:

nachricht Warming ponds could accelerate climate change
21.02.2017 | University of Exeter

nachricht An alternative to opioids? Compound from marine snail is potent pain reliever
21.02.2017 | University of Utah

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>