Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists Identify Compounds That Mimic Calorie Restriction

11.08.2004


Investigators from an international consortium of research institutes, including the Johns Hopkins Bloomberg School of Public Health, have identified compounds that mimic the effects of a low calorie diet without changing the amount of essential nutrients. The researchers believe it may be possible to design drugs that imitate many of the beneficial effects of calorie restriction resulting in the prevention of diseases, such as diabetes, heart disease and cancer, which are more common in people who are overweight. Their findings are published in the current online issue of the Journal of Biological Chemistry.



Co-author Thomas W. Kensler, PhD, a professor of Environmental Health Sciences at the Johns Hopkins Bloomberg School of Public Health, explained that calorie restriction has intrigued scientists for decades because it increases the life span of almost every species studied. In mammals, calorie restriction suppresses many diseases associated with the obesity epidemic. However, the mechanisms by which calorie restriction suppresses these diseases are not known.

Lead author, J. Christopher Corton, PhD, with ToxicoGenomics in Chapel Hill, N.C., examined the genetic changes that occur during calorie restriction in mice that were fed a diet for one month containing about 35 percent fewer calories than a normal diet. He explained that these genetic changes, which are referred to as a transcript profile, can be used like a bar-code to distinguish a unique profile from other genetic changes that occur in the body. The researchers compared the profile of calorie restriction with the profiles produced by compounds known to have some properties similar to calorie restriction, including the ability to suppress factors that lead to a number of diseases.


The compounds that shared the greatest similarities in the bar codes included those that have activity towards receptors of interest to the pharmaceutical industry. The receptors include those that are targeted by drugs used to treat high cholesterol and triglyceride levels. One of the receptors, called PPARalpha, is a target for drugs that are currently used to treat high cholesterol and triglyceride levels in people at risk for heart disease.

The investigators also compared responses in normal mice to mice that lack a functional PPARalpha to determine if PPARalpha was directly involved in any of the responses that are induced by calorie restriction. They found that the PPARalpha-mutant mice lack many of the characteristics of calorie restriction, including changes in genes that may play important roles in heart disease and cancer. Calorie restriction is also known to protect animals from chemical exposure, and the investigators found that the protection afforded by calorie restriction in normal mice was lost in PPARalpha-mutant mice.

“PPARalpha may be one of a handful of receptors that play important roles in mediating the beneficial effects of calorie restriction. Our findings could be used to take a rational approach to designing drugs that mimic beneficial aspects of calorie restriction,” said Harihara M. Mehendale, PhD, senior author and professor and Kitty DeGree Endowed Chair in Toxicology at the University of Louisiana at Monroe.

“Mimetics of Calorie Restriction Include Agonists of Lipid-activated Nuclear Receptors” was written by J. Christopher Corton, Udayan Apte, Steven P. Anderson, Pallavi Limaye, Lawrence Yoon, John Latendresse, Corrie Dunn, Jeffrey I. Everitt, Kenneth A. Voss, Cynthia Swanson, Carie Kimbrough, Jean S. Wong, Sarjeet S. Gill, Roshantha A. S. Chandraratna, Mi-Kyoung Kwak, Thomas W. Kensler, Thomas M. Stulnig, Knut R. Steffensen, Jan-Ake Gustafsson and Harihara M. Mehendale.

The study was supported by grants from the National Institute of Environmental Health Sciences, Louisiana Board of Regents Support fund, Marie Curie Fellowship of the European Community program Human Potential, Swedish Science Council and KaroBio.

Kenna L. Lowe | EurekAlert!
Further information:
http://www.jhsph.edu

More articles from Life Sciences:

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

nachricht CWRU researchers find a chemical solution to shrink digital data storage
22.06.2017 | Case Western Reserve University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

Im Focus: Optoelectronic Inline Measurement – Accurate to the Nanometer

Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.

New Manufacturing Technologies for New Products

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

A new technique isolates neuronal activity during memory consolidation

22.06.2017 | Life Sciences

Plant inspiration could lead to flexible electronics

22.06.2017 | Materials Sciences

A rhodium-based catalyst for making organosilicon using less precious metal

22.06.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>