A schematic representation of the genomic events associated with breast cancer progression, including the occurrence of telomere crisis.
These confocal microscope images highlight regions of chromosomes in cells of a breast duct exhibiting hyperplasia (left) and one exhibiting carcinoma in situ (right).
Telomere crisis is an important early event in the development of breast cancer, and its occurrence can be identified with precision, according to recent findings by a team of scientists at the Department of Energy’s Lawrence Berkeley National Laboratory and the University of California at San Francisco. Their report is now available through advance online publication of Nature Genetics.
Joe Gray, director of Berkeley Lab’s Life Sciences Division and a professor of laboratory medicine and radiation oncology at UCSF, is one of the paper’s lead authors, with Koei Chin and Britt Marie Ljung of UCSF; Carlos Ortiz de Solorzano, Paul Yaswen, and Martha Stampfer of Berkeley Lab; and Stephen J. Lockett from the National Cancer Institute.
In the breast, cells in a milk-collecting duct occasionally proliferate excessively due to development of a regulatory defect. Gray and his colleagues postulate that this results in a lesion called "usual ductal hyperplasia."
Paul Preuss | EurekAlert!
Water forms 'spine of hydration' around DNA, group finds
26.05.2017 | Cornell University
How herpesviruses win the footrace against the immune system
26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy