Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

More aggressive breast cancer tumors found in African American women

09.08.2004


A genetic mutation related to a more aggressive form of breast cancer occurs four times more often in African American patients than their white counterparts, Yale researchers report in the August 9, 2004 online edition of the journal Cancer.

In the United States, African-American women have a lower incidence of breast cancer than white women, but they have a higher mortality rate. The disease also develops at an earlier age and is more aggressive in African-American women. To explore the reasons for the differences, Beth A. Jones, assistant professor in the Department of Epidemiology and Public Health at Yale School of Medicine, and her colleagues studied the effects of alterations in a tumor suppressor gene called p53.

The team looked at how the patterns of alterations of genes related to worse prognosis differed between African-American and white women. They examined the breast tumors of 145 African-American and 177 white women and found that African-American women were four times more likely than white women to show significant alterations in the p53 gene.



"This is the first population-based study to report a clearly significant increase in p53 mutations that is independent of race differences in other tumor characteristics, socioeconomic status and other biomedical and lifestyle factors", said Jones. The authors also confirmed that tumors in African-American women were more likely than those in whites to display tumor characteristics associated with poor prognosis. With few population-based studies having access to detailed patient information and tumor information assessed in a single laboratory using standardized methodology, Jones said confirmation of these earlier reports is an important contribution to this area of research.

Past explanations for the racial/ethnic differences included socioeconomic factors, nutrition and healthcare behavior, but Jones stresses that while many factors contribute to the relatively poor outcome for some African-American breast cancer patients, understanding the underlying mechanisms is critical.

"Our goal is to continue to illuminate the reasons for the differences, so we can ultimately develop prevention strategies and tailor treatments more effectively," said Jones.

Other authors on the study include Stanislav V. Kasl, Christine L. Howe, Mary Lachman, Robert Dubrow, Mary McCrea Curnen, Hosanna Soler-Vila, Alicia Beeghly, Fenghai Duan and Patricia Owens.

Karen N. Peart | EurekAlert!
Further information:
http://www.yale.edu

More articles from Life Sciences:

nachricht Light-driven reaction converts carbon dioxide into fuel
23.02.2017 | Duke University

nachricht Oil and gas wastewater spills alter microbes in West Virginia waters
23.02.2017 | Rutgers University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Organ-on-a-chip mimics heart's biomechanical properties

23.02.2017 | Health and Medicine

Light-driven reaction converts carbon dioxide into fuel

23.02.2017 | Life Sciences

Oil and gas wastewater spills alter microbes in West Virginia waters

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>