Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Novel Stem Cell in Blood and Vessel Formation Identified

26.07.2004


A research study published this week has for the first time identified the specific precursor stem cell that gives rise not only to the important cells lining our blood vessels but also the blood itself.



Dr. Mick Bhatia and his colleagues at Robarts Research Institute in London, Ontario, had demonstrated last year that human embryonic stem cells (hESCs) can make blood cells; and they and others have known for some time that there is a connection between the development of the blood and the formation of the vessels it flows through. Now, Dr. Bhatia has traced the development of these interrelated systems back to a specific population of primitive endothelial-like cells in the lining of the earliest blood vessels. His findings are published in this week’s edition of the journal Immunity.

Understanding this common lineage of blood and cells comprising veins and arteries provides a powerful tool to test ideas about how these human precursor cells could potentially be transplanted to repair damaged tissue or organs, such as in cases of trauma or injury where vessels have been torn and major blood loss has occurred, or in cancer to “turn off” the formation of blood vessels that feed a growing tumour.


“We think we’ve identified a version of human blood precursors that may be the most potent of blood cells -- the one that has the greatest developmental potential to promote repair of vessels as well as regeneration of the blood itself,” explained Dr. Bhatia, Director of the Krembil Centre for Stem Cell Biology at Robarts. “This precursor cell provides an important new tool in our biological toolkit that can help us understand precisely how stem cells give rise to the tissues and organs of the body -- and how we can harness that potential to minimize the damage of injury and disease.”

Still, Dr. Bhatia, who is also an associate professor of microbiology and immunology at The University of Western Ontario, stresses that much fundamental biology remains in stem cell research.

Before new therapies can be developed, tested and safely used in humans, researchers continue to refine methods in identifying, purifying and verifying rare and elusive stem cells for study. They are also identifying what genes are important in the development and differentiation of these cells, what genes are linked to blood cancers, such as leukemias, and which particular growth factors can have a stimulating -- or inhibiting -- effect on stem cell development.

| newswise
Further information:
http://www.robarts.ca

More articles from Life Sciences:

nachricht A Map of the Cell’s Power Station
18.08.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

nachricht On the way to developing a new active ingredient against chronic infections
18.08.2017 | Deutsches Zentrum für Infektionsforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>