Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Novel Stem Cell in Blood and Vessel Formation Identified

26.07.2004


A research study published this week has for the first time identified the specific precursor stem cell that gives rise not only to the important cells lining our blood vessels but also the blood itself.



Dr. Mick Bhatia and his colleagues at Robarts Research Institute in London, Ontario, had demonstrated last year that human embryonic stem cells (hESCs) can make blood cells; and they and others have known for some time that there is a connection between the development of the blood and the formation of the vessels it flows through. Now, Dr. Bhatia has traced the development of these interrelated systems back to a specific population of primitive endothelial-like cells in the lining of the earliest blood vessels. His findings are published in this week’s edition of the journal Immunity.

Understanding this common lineage of blood and cells comprising veins and arteries provides a powerful tool to test ideas about how these human precursor cells could potentially be transplanted to repair damaged tissue or organs, such as in cases of trauma or injury where vessels have been torn and major blood loss has occurred, or in cancer to “turn off” the formation of blood vessels that feed a growing tumour.


“We think we’ve identified a version of human blood precursors that may be the most potent of blood cells -- the one that has the greatest developmental potential to promote repair of vessels as well as regeneration of the blood itself,” explained Dr. Bhatia, Director of the Krembil Centre for Stem Cell Biology at Robarts. “This precursor cell provides an important new tool in our biological toolkit that can help us understand precisely how stem cells give rise to the tissues and organs of the body -- and how we can harness that potential to minimize the damage of injury and disease.”

Still, Dr. Bhatia, who is also an associate professor of microbiology and immunology at The University of Western Ontario, stresses that much fundamental biology remains in stem cell research.

Before new therapies can be developed, tested and safely used in humans, researchers continue to refine methods in identifying, purifying and verifying rare and elusive stem cells for study. They are also identifying what genes are important in the development and differentiation of these cells, what genes are linked to blood cancers, such as leukemias, and which particular growth factors can have a stimulating -- or inhibiting -- effect on stem cell development.

| newswise
Further information:
http://www.robarts.ca

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>