Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Novel Stem Cell in Blood and Vessel Formation Identified

26.07.2004


A research study published this week has for the first time identified the specific precursor stem cell that gives rise not only to the important cells lining our blood vessels but also the blood itself.



Dr. Mick Bhatia and his colleagues at Robarts Research Institute in London, Ontario, had demonstrated last year that human embryonic stem cells (hESCs) can make blood cells; and they and others have known for some time that there is a connection between the development of the blood and the formation of the vessels it flows through. Now, Dr. Bhatia has traced the development of these interrelated systems back to a specific population of primitive endothelial-like cells in the lining of the earliest blood vessels. His findings are published in this week’s edition of the journal Immunity.

Understanding this common lineage of blood and cells comprising veins and arteries provides a powerful tool to test ideas about how these human precursor cells could potentially be transplanted to repair damaged tissue or organs, such as in cases of trauma or injury where vessels have been torn and major blood loss has occurred, or in cancer to “turn off” the formation of blood vessels that feed a growing tumour.


“We think we’ve identified a version of human blood precursors that may be the most potent of blood cells -- the one that has the greatest developmental potential to promote repair of vessels as well as regeneration of the blood itself,” explained Dr. Bhatia, Director of the Krembil Centre for Stem Cell Biology at Robarts. “This precursor cell provides an important new tool in our biological toolkit that can help us understand precisely how stem cells give rise to the tissues and organs of the body -- and how we can harness that potential to minimize the damage of injury and disease.”

Still, Dr. Bhatia, who is also an associate professor of microbiology and immunology at The University of Western Ontario, stresses that much fundamental biology remains in stem cell research.

Before new therapies can be developed, tested and safely used in humans, researchers continue to refine methods in identifying, purifying and verifying rare and elusive stem cells for study. They are also identifying what genes are important in the development and differentiation of these cells, what genes are linked to blood cancers, such as leukemias, and which particular growth factors can have a stimulating -- or inhibiting -- effect on stem cell development.

| newswise
Further information:
http://www.robarts.ca

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>