A molecule found in nearly all cells plays a vital role in kick-starting the production of key biological molecules involved in inflammation, a group of Salk Institute scientists has discovered. The finding, published in the June 25 issue of Science, may lead to new strategies for blocking the devastating inflammation that lies at the heart of autoimmune disorders such as multiple sclerosis, arthritis, lupus as well as some cancers.
When the cells of the body are confronted with toxic chemicals or disease-causing organisms, such as viruses and bacteria, the immune system mobilizes rapidly to produce an inflammatory response. This army of chemical and cellular defenses is unleashed through a complex chain of molecular events, triggered by master control proteins. These control proteins act as recruiting officers, rallying other proteins to set up the inflammatory defense. One of the most important molecular sergeants is a protein called nuclear factor-kappa B (NF-kB), which can order the production of scores of defensive proteins.
But NF-kB can’t work alone; it requires the help of a complicated complex of other proteins. A team of scientists which included Jeanette Ducut Sigalla, Virgine Bottero and Inder Verma from the Salk Institute together with colleagues from CellGene found that a protein called ELKS is a crucial member of this complex. Verma’s team determined that when ELKS was missing, NF-kB was unable to activate the production of proteins involved in inflammation.
Andrew Porterfield | EurekAlert!
Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH
Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences