Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A Mother’s Obesity Can Cause Malformations In Her Children

16.07.2004


A study of more than 2000 children of women with gestational diabetes (the diabetes that some women get during pregnancy) has revealed that obesity in mothers is one of the most decisive factors contributing to the appearance of congenital malformations in their children, even more so than the seriousness of the diabetes. The research, published in the european journal Diabetologia, has been carried out by a research team from the Universitat Autònoma de Barcelona and Hospital de Sant Pau in Barcelona.



It has been known since the 1960s that children of women with diabetes before pregnancy have a higher possibility of having congenital malformations, which are primarily related with the mother’s degree of hyperglycemia (high blood sugar) during the period in which the embryo’s organs are forming. In the children of women with gestational diabetes, which is first detected during pregnancy, the risk of malformations does not increase so much, but it still exists. In this case, during the period when the embryo’s organs are forming the glucose levels are usually fairly unaltered.

A research team from the Universitat Autònoma de Barcelona and the Hospital de Sant Pau headed by Doctor Rosa Corcoy have come to an unexpected conclusion after analysing the relationship between the mother’s glucose levels and congenital malformations in the children of mothers with gestational diabetes. Surprisingly, the body mass index, which indicates obesity, is more important for predicting malformations than other variables that indicate the seriousness of the maternal diabetes mellitus.


In a study of 2060 children, the researches decided to include the body mass index as a variable for the statistical analysis now that it has been demonstrated that obesity plays a part in congenital malformations in embryos, especially those related to the heart and the central nervous system. According to the study’s results, the mother’s degree of obesity is the main predicting factor for cardiac malformations and minor malformations, and the only factor able to predict renal and urinary tract malformations. The seriousness of the mother’s gestational diabetes, however, was the only factor that could predict skeletal malformations.

Previous studies have not identified the degree of obesity as contributing to the risk of cardiac malformations in the children of woman with gestational diabetes, possibly because this variable wasn’t included in the statistical analysis.

The authors of the study suggest two possible explanations for obesity’s important role in congenital malformations. Obesity is an indicator of energy availability and of all the nutrients that provide energy; the excess of these nutrients, and not only glucose, is linked with the appearance of malformations. In addition, both the excess and deficiency of insulin can provoke malformations in the embryo, and in the case of obesity, the fact that there is a resistance to the effects of the insulin results in higher concentrations.

Octavi López Coronado | alfa
Further information:
http://www.uab.es

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>