Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Dog genome assembled


Canine genome available now to research community worldwide

Tasha, the boxer whose DNA was sequenced

The first draft of the dog genome sequence has been deposited into free public databases for use by biomedical and veterinary researchers around the globe, the National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH), announced today.

A team led by Kerstin Lindblad-Toh, Ph.D., of the Broad Institute of MIT and Harvard, Cambridge, Mass., and Agencourt Bioscience Corp., Beverly, Mass., successfully assembled the genome of the domestic dog (Canis familiaris). The breed of dog sequenced was the boxer, which was chosen after analyses of 60 dog breeds found it was one of the breeds with the least amount of variation in its genome and therefore likely to provide the most reliable reference genome sequence.

The initial assembly is based on seven-fold coverage of the dog genome. Researchers can access the sequence data through the following public databases: GenBank ( at NIH’s National Center for Biotechnology Information (NCBI); EMBL Bank ( at the European Molecular Biology Laboratory’s Nucleotide Sequence Database; and the DNA Data Bank of Japan ( The data can also be viewed through the UCSC Genome Browser ( at the University of California at Santa Cruz and the Ensembl Genome Browser ( at the Wellcome Trust Sanger Institute in Cambridge, England. Viewing capabilities also will be available in August at NCBI’s Map Viewer (

The NHGRI-supported researchers are currently comparing the dog and human genome sequences and plan to publish results of their analysis in the next several months.

The dog genome is similar in size to the genomes of humans and other mammals, containing approximately 2.5 billion DNA base pairs. Due to a long history of selective breeding, many types of dogs are prone to genetic diseases that are difficult to study in humans, such as cancer, heart disease, deafness, blindness and autoimmune disorders. In addition, the dog is an important model for the genetics of behavior and is used extensively in pharmaceutical research.

To best characterize disease in dogs, it is important to have a sufficient number of markers in the genome. Therefore, in addition to the boxer, nine other dog breeds, four wolves and a coyote were sampled to generate markers that can be used in disease studies in any dog breed. A preliminary set of about 600,000 single nucleotide polymorphisms (SNPs), which amounts to a SNP roughly every 5,000 DNA base pairs, is currently being aligned to the released assembly. The reads used to identify the SNPs are publicly available in NCBI’s Trace Archive ( and the SNPs will be available shortly at the Single Nucleotide Polymorphism database, dbSNP (

Sequencing of the dog genome began in June 2003. NHGRI provided about $30 million in funding for the project to the Broad Institute, which is part of NHGRI’s Large-Scale Sequencing Research Network.

To learn more about the rapidly expanding field of comparative genomic analysis, go to: To read the white paper that outlines the scientific rationale and strategy for sequencing the dog genome, go to:

| EurekAlert!
Further information:

More articles from Life Sciences:

nachricht Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München

nachricht Second research flight into zero gravity
21.10.2016 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>