European researchers tackle mitosis
EMBL and partners begin MitoCheck, a multinational research project on cell cycle regulation
Scientists at the European Molecular Biology Laboratory (EMBL) join forces with top scientists from eleven research institutes in Austria, Germany, Italy, France and the United Kingdom for "MitoCheck" - the largest integrated research project on cell cycle control within the European Commission’s 6th Framework Programme (FP6). The partners will receive an 8.5 million Euro grant to address a fundamental question: How is cell division regulated?
Cell division (or "mitosis") is one of the key processes of life. Mistakes during mitosis can cause infertility and mental retardation, and can contribute to cancer. For the most part, mitosis is still poorly understood. Scientists do know that protein kinases - a certain type of enzyme - play a key role, but researchers don’t know how these enzymes bring about the important changes in cells that cause them to divide. To understand cell division in a comprehensive manner, the MitoCheck consortium of European scientists will systematically hunt for all genes that are required for division and then check the products of these genes to see how they are regulated by mitotic kinases.
"This project is vital to understanding one of the most basic processes of life - making two cells out of one. Here at EMBL, we will identify which genes are required for mitosis by suppressing them gene-by-gene in live human cells and testing whether they can still divide afterwards," notes Jan Ellenberg, EMBL Group Leader and co-initiator of the MitoCheck project.
To achieve this, EMBL scientists use a method called "RNA interference," where RNA molecules can target and silence specific genes involved in mitosis. Another MitoCheck partner, the Max-Planck Institute of Cell Biology and Genetics in Dresden will provide a vast library of these molecules. About 20,000 genes will be suppressed one-by-one and EMBL researchers will make movies of the cells undergoing division, using sophisticated microscopes developed by Rainer Pepperkok, Jan Ellenberg and Leica Microsystems. Several hundred thousand movies will be produced, filming each group of cells over a 48-hour period, to capture the full impact of silencing particular genes. The task of analyzing the enormous amount of data will be accomplished in a close collaboration of scientists at EMBL and the German Cancer Research Centre (DKFZ).
The end result of the work at EMBL will be a comprehensive list of genes required for mitosis in human cells. But most importantly, for the first time, scientists will know exactly which genes are active during mitosis and what happens in the cell when these genes are suppressed. This information will be used by all the partners in this European project to determine the biochemical regulation of mitotic genes, and to test them as tools for cancer diagnosis. All data produced through MitoCheck will be readily available to the scientific community and the public - through databases at the DKFZ, and at The Wellcome Trust Sanger Institute, another MitoCheck partner.
"This project is an excellent example of a European research network," Jan Ellenberg says. "We have assembled a group of top scientists across Europe, each of whom is contributing an essential piece towards a common goal - understanding mitosis."
Trista Dawson | EMBL
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...