Study describes new approach to treating AIDS-associated syndrome
Increasing the body’s production of growth hormone may be an effective treatment for HIV lipodystrophy, a syndrome involving the redistribution of fat and other metabolic changes in those receiving combination drug therapy for HIV infection. Researchers from Massachusetts General Hospital (MGH) report that administration of growth-hormone-releasing hormone to a group of men with HIV lipodystrophy significantly improved fat distribution with no negative side effects. The study appears in the July 14 Journal of the American Medical Association, a special HIV/AIDS issue published in conjunction with the International AIDS Conference in Bangkok.
"This study is an initial proof of principal that augmenting low growth hormone levels in this way has the potential to reverse the abnormal body composition seen in these individuals," says Steven Grinspoon, MD, of the MGH Neuroendocrine Unit and Program in Nutritional Metabolism, the report’s senior author. "At the current time, there is no established treatment for this syndrome."
Sue McGreevey | EurekAlert!
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