Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study of metastasis

09.07.2004


Metastasis of cancer may cause as many, if not more, deaths than cancer itself. Amongst other reasons, this is because it is very difficult to know where the new tumour is going to develop. Moreover, the mechanisms of metastasis are still not well understood, although a lot of research into it is taking place and advances are being made. Dominion Pharmakine is a company located at the Bizkaia Technological Park where they are studying metastasis.




At times, a cell in our body may suffer a mutation and starts to multiply in an uncontrolled manner. All the cells thus formed result in a tumour which interferes in the form and functions of the tissue of which it is part. Moreover, the tumour provokes the creation of new blood vessels, which assures a good food supply.

If the tumour limits itself to growing, it is said to be a benign tumour and, in most cases, does not require treatment. But, if malignant, it must be treated. If not extirpated, pharmaceutical drugs have to be used to combat the tumour. But the tumour usually has a number of defence mechanisms. One of these is a proteic layer difficult to penetrate by some of these drugs. Dominion Pharmakine is studying which these area and also the suitability of the molecular targets used by the new drugs for bonding to the pathological cells, i.e. they are trying to identify the molecule that best offers the possibility of penetration of the unhealthy cell.


But unfortunately, malign tumours, apart from growing, may spread throughout the body, i.e. they may produce a metastasis. Some of the cells separate from the tumour and are carried to other parts of the body through the blood system, via the newly-formed vessels. Once in the blood system, it is distributed through the whole body until they attach themselves to some new tissue and initiate a new tumour.

Metastasis initiates as a consequence of two changes in the genetic expression and protein synthesis that occur in the initial tumour. Dominion Pharmakine is also investigating the relationship between this genetic expression and metastasis. From this information, two objectives are sought: on the one hand, predicting the evolution of the tumour using the genetic expression arising and, on the other, designing new specific drugs based on this expression.

The Dominion Pharmakine company was formed as a spin off of the Faculty of Medicine at the University of the Basque Country.

Eneko Imaz | Basque Research
Further information:
http://www.pharmakine.com
http://www.elhuyar.com

More articles from Life Sciences:

nachricht The dense vessel network regulates formation of thrombocytes in the bone marrow
25.07.2017 | Rudolf-Virchow-Zentrum für Experimentelle Biomedizin der Universität Würzburg

nachricht Fungi that evolved to eat wood offer new biomass conversion tool
25.07.2017 | University of Massachusetts at Amherst

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA mission surfs through waves in space to understand space weather

25.07.2017 | Physics and Astronomy

Strength of tectonic plates may explain shape of the Tibetan Plateau, study finds

25.07.2017 | Earth Sciences

The dense vessel network regulates formation of thrombocytes in the bone marrow

25.07.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>