Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

U of T Team Develops Mutated Yeast Strains To Aid Geneticists

09.07.2004


University of Toronto microbiologists have used pattern recognition software to discover the function of yeast genes essential to cell life - knowledge that could help scientists determine what causes cells to die, as well as what they need to live.

"Given the similarities between the yeast and human genomes, our work should promote advances in genomics research in both yeast and humans," said Professor Timothy Hughes of U of T’s Department of Medical Genetics and Microbiology, who led the research team.

A paper published in the July 9 issue of the journal Cell describes how the researchers engineered mutations to 700 of the 1,000 yeast genes that are essential to cell life. They analyzed the mutant strains by making several basic measurements -- cell size, cell shape and gene levels - and by evaluating a cell’s potential to grow in a variety of media. They then took these data and did computerized analysis of entire categories of genes in order to predict the functions of individual genes, applying a standard technique for pattern discovery used in fields ranging from marketing to face recognition.



"It’s similar to ordering a book from Amazon.com," said Hughes. "After you’ve placed an order, they use the information they’ve gathered to predict your likes and dislikes. The next time you log onto the computer, they extrapolate and suggest other books you might enjoy. They also could use the data to predict other things - for example, your age and your gender - which might, on the surface, seem unrelated to books."

"We’re hoping our use of this technique to predict the function of yeast genes is going to become a classical example of how to do this in biology."

To create each mutated strain, the researchers used a technique in which adding the drug doxycycline to the yeast cells disables an individual gene. This technique is a reliable alternative to the more common method of causing mutations by radiation, because the mutations are engineered rather than random.

The 700 yeast strains developed by Hughes’ team are now available commercially to other researchers and 300 more strains are under development. Yeast is a staple of genomic research because many human genes are similar to yeast genes.

This research was funded by the Canadian Institutes of Health Research and Genome Canada.

Contact:

Timothy Hughes Elaine Smith
Department of Medical Genetics & Microbiology U of T Public Affairs

416-946-8260
t.hughes@utoronto.ca

416-978-5949
elaine.smith@utoronto.ca

Timothy Hughes | University of Toronto
Further information:
http://www.utoronto.ca

More articles from Life Sciences:

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

nachricht Research reveals how order first appears in liquid crystals
23.05.2018 | Brown University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Research reveals how order first appears in liquid crystals

23.05.2018 | Life Sciences

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>