Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

King Crab Heals Scalds And Sores

02.07.2004


Of course, not the crab itself, but its hepatopancreas, which is a gland performing functions of both liver and pancreas. And not an entire hepatopancreas, but only some of its enzymes isolated by the Moscow scientists supported by the Russian Foundation for Basic Research (RFBR) and Foundation for Assistance to Small Innovative Enterprises (FASIE).



Doctor of chemical sciences Galina Rudenskaya from the Moscow State University and her colleagues from small enterprise TRINITA have made an important discovery in medicine, thanks to funding extended by the RFBR and FASIE.

The preparation based on enzymes extracted from king crab’s hepatopancreas (gland performing functions of both liver and pancreas) heals scalds, sores, and trophic ulcers that were either incurable or hardly curable before. Surgeons that participate in trials are eager to get some "crab grease". But only a very small amount of the ointment has been obtained by now, and it still needs to be approved by the Pharmacological Committee. And only 100 grams of enzymes that are active components of the ointment have been isolated. However, technique for their isolation and purification has already been developed and patented.


So, the preparation is based on enzymes, so-called, proteases. The most important among them, collagenase, catalyzes the hydrolysis of collagen that is a tough fibrous protein constituent of bone, tendon, and skin. It is collagen that makes the skin resilient, water-proof, and resistant to various agents. Most active collagenases are extracted from pathogenic microorganisms causing gas gangrene. Hence, the extraction of such collagenases is a labour-consuming and risky process. But collagenase is also contained in the hepatopancreas of king crab, in non-hazardous surroundings of crab’s intestines.

Collagenase is needed for the following. In case of a serious damage of the skin (a scald, scar remaining after an operation, or trophic ulcers), the wound healing is impeded by small fragments of tissues, particularly, collagen remaining there. Those cannot be decomposed to single molecules because of an absence of essential enzyme, collagenase. Hence, those fragments of tissues decay and cause necrosis. The wound heals slowly and difficultly, with the appearance of pus and ugly scars.

The preparation developed by the University chemists contains collagenase itself and some other enzymes. By the expression of Rudenskaya, "collagenase tears collagen into pieces that are further chewed by other enzymes".

Afterwards, the wound healing requires a building material for a new elastic skin, which is supplied by preparation "Eikonol" developed by the enterprise TRINITA headed by V.A. Isaev. The active component of the latter is extracted from fish. Thus, all components of the medicine are obtained from food objects and don’t cause undesirable side effects. Raw materials used in the medicine manufacture are cheap wastes of fishing and crabbing.

The scientists have also invented a new technique for extracting active enzymes from crab’s internal organs and their purifying. This is so-called affine chromatography, for which special sorbents have been synthesized. The extract containing various necessary and unnecessary compounds moves through columns filled by the sorbents.

The latter consist of a silica-containing material bond with molecules of antibiotic, whose basket-like structure catches needed enzymes, proteases, from the solution. Thus, proteases are retained in the sorbent, and all admixtures pass by.

All together, that resembles a rod with bait tasty for a single fish species. Then, proteases are washed off by another solution, concentrated using a nontrivial technique developed by the scientists, and dried. Provided that obtained powder is properly stored (in a freezer at -20 degrees Celsius), its medical properties can be preserved for many years. When the laboratory technique will be adjusted to the pharmaceutical industry (the scientists believe they can do that very soon), there will be enough enzymes for everybody.

Sergey Komarov | alfa
Further information:
http://www.genebee.msu.su

More articles from Life Sciences:

nachricht Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Multiregional brain on a chip

16.01.2017 | Power and Electrical Engineering

New technology enables 5-D imaging in live animals, humans

16.01.2017 | Information Technology

Researchers develop environmentally friendly soy air filter

16.01.2017 | Power and Electrical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>