Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Scientists discover molecular target for treatment of T cell acute lymphoblastic leukemia


A new research study published in the June issue of Cancer Cell identifies the molecular events that contribute to a notoriously treatment-resistant form of T cell leukemia.

The findings reveal that disruption of immune cell differentiation is central to disease progression and provide new avenues for development of future therapeutics.

T cell acute lymphoblastic leukemia (T-ALL) accounts for 10%-15% of pediatric and 25% of adult ALL cases. A gene called TAL1/SCL is frequently activated in T-ALL patients, but exactly how it causes leukemia has not been clear.

Dr. Michelle Kelliher, from the Department of Cancer Biology at the University of Massachusetts Medical School in Worcester, Massachusetts, and colleagues examined how the TAL1/SCL protein contributes to leukemia.

The researchers demonstrate that TAL1/SCL induces leukemia by interfering with a protein called E47/HEB that regulates the expression of many different genes required for immune cell differentiation and survival.

When these genes were experimentally inhibited by TAL1/SC1 in mice, the mice exhibited abnormal immune (T cell) development, and most eventually developed leukemia.

The researchers also showed that TAL1/SCL silences gene expression by recruiting a histone deacetylase (HDAC) repressor complex, and in fact, HDAC inhibitors were very effective at inhibiting the growth of TAL1/SCL tumor cells.

"Our work demonstrates that TAL1/SCL induces leukemia by repressing E47/HEB activity, and suggests that HDAC inhibitors may prove efficacious in T-ALL patients who express TAL1/SCL. This is an important discovery, as these particular patients respond poorly to current chemotherapies and are at high risk for treatment failure," says Dr. Kelliher.

Jennifer O’Neil, Jennifer Shank, Nicole Cusson, Cornelius Murre, and Michelle Kelliher: "TAL-1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB"

Published in Cancer Cell, Volume 5, Number 6, June 2004.

Heidi Hardman | EurekAlert!
Further information:

More articles from Life Sciences:

nachricht Don't Give the Slightest Chance to Toxic Elements in Medicinal Products
23.03.2018 | Physikalisch-Technische Bundesanstalt (PTB)

nachricht North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Space observation with radar to secure Germany's space infrastructure

Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.

The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...

Im Focus: Researchers Discover New Anti-Cancer Protein

An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.

The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...

Im Focus: Researchers at Fraunhofer monitor re-entry of Chinese space station Tiangong-1

In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.

Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...

Im Focus: Alliance „OLED Licht Forum“ – Key partner for OLED lighting solutions

Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.

They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

New solar solutions for sustainable buildings and cities

23.03.2018 | Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

Latest News

For graphite pellets, just add elbow grease

23.03.2018 | Materials Sciences

Unique communication strategy discovered in stem cell pathway controlling plant growth

23.03.2018 | Agricultural and Forestry Science

Sharpening the X-ray view of the nanocosm

23.03.2018 | Physics and Astronomy

Science & Research
Overview of more VideoLinks >>>