Using a common worm as a model, researchers from Duke University Medical Center have identified specific genes within Salmonella that give the bacteria its ability to infect host cells.
Alejandro Aballay, Ph.D.
CREDIT: Duke University Medical Center
They said their findings could ultimately lead to improved drugs to prevent or treat Salmonella infections.
The researchers found four genes related to the Salmonellas "molecular syringe" that are required for the bacteria to have maximum potency in infecting the worm, known as Caenorhabditis elegans. The virulence factors -- injected into the host cells by Salmonella -- act by blunting the innate immune system of C. elegans from attacking and destroying the infecting bacteria.
Richard Merritt | dukemed news
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